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      In Vitro Permeation and Skin Retention of α-Mangostin Proniosome.

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          Abstract

          The current investigation evaluated the potential of proniosome as a carrier to enhance skin permeation and skin retention of a highly lipophilic compound, α-mangostin. α-Mangostin proniosomes were prepared using the coacervation phase seperation method. Upon hydration, α-mangostin loaded niosomes were characterized for size, polydispersity index (PDI), entrapment efficiency (EE) and ζ-potential. The in vitro permeation experiments with dermis-split Yucatan Micropig (YMP) skin revealed that proniosomes composed of Spans, soya lecithin and cholesterol were able to enhance the skin permeation of α-mangostin with a factor range from 1.8- to 8.0-fold as compared to the control suspension. Furthermore, incorporation of soya lecithin in the proniosomal formulation significantly enhanced the viable epidermis/dermis (VED) concentration of α-mangostin. All the proniosomal formulations (except for S20L) had significantly (p<0.05) enhanced deposition of α-mangostin in the VED layer with a factor range from 2.5- to 2.9-fold as compared to the control suspension. Since addition of Spans and soya lecithin in water improved the solubility of α-mangostin, this would be related to the enhancement of skin permeation and skin concentration of α-mangostin. The choice of non-ionic surfactant in proniosomes is an important factor governing the skin permeation and skin retention of α-mangostin. These results suggested that proniosomes can be utilized as a carrier for highly lipophilic compound like α-mangostin for topical application.

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          Author and article information

          Journal
          Chem Pharm Bull (Tokyo)
          Chemical & pharmaceutical bulletin
          Pharmaceutical Society of Japan
          1347-5223
          0009-2363
          2016
          : 64
          : 12
          Affiliations
          [1 ] Institute of Bioproduct Development, Universiti Teknologi Malaysia.
          Article
          10.1248/cpb.c16-00425
          27904075
          afbcf0b2-5a00-4545-98ec-307091a936c4
          History

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