Contributors
Patrick Meagher:
ORCID: https://orcid.org/0000-0002-0221-3806
Role: Data curationRole: Formal analysisRole: SupervisionRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Robert Civitarese: Role: Data curationRole: Formal analysisRole: VisualizationRole: Writing – original
draft
Xavier Lee:
ORCID: https://orcid.org/0000-0002-8158-6183
Role: Formal analysisRole: Writing – original draft
Mark Gordon: Role: Data curationRole: Formal analysis
Antoinette Bugyei-Twum: Role: Data curationRole: Formal analysisRole: Project administrationRole: Supervision
Jean-Francois Desjardins: Role: Formal analysisRole: MethodologyRole: SoftwareRole: Writing – review & editing
Golam Kabir: Role: InvestigationRole: Methodology
Yanling Zhang: Role: InvestigationRole: Methodology
Hari Kosanam: Role: InvestigationRole: MethodologyRole: Software
Aylin Visram: Role: Data curationRole: Formal analysis
Howard Leong-Poi: Role: ConceptualizationRole: InvestigationRole: Writing – review & editing
Andrew Advani: Role: ConceptualizationRole: MethodologyRole: Writing – review & editing
Kim A. Connelly: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: Writing
– original draftRole: Writing – review & editing
Vincenzo Lionetti: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
24
June
2021
Publication date Collection: 2021
Volume: 16
Issue: 6
Electronic Location Identifier: e0252711
Affiliations
[1
]
St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto,
Canada
[2
]
Department of Physiology, University of Toronto, Toronto, Canada
[3
]
Institute of Medical Science, University of Toronto, Toronto, Canada
Scuola Superiore Sant’Anna, ITALY
Author notes
Competing Interests: The authors have read the journal’s policy and have the following competing interests:
KAC has received research grants to his institution from Astra Zeneca and Boehringer
Ingelheim, received support for travel to scientific meeting from Boehringer Ingelheim,
and received honoraria for speaking engagements and ad hoc participation in advisory
boards from Astra Zeneca, Boehringer Ingelheim, and Janssen. There are no patents,
products in development or marketed products associated with this research to declare.
This does not alter our adherence to PLOS ONE policies on sharing data and materials.
‡ These authors are co-first authors on this work.
Author information
Article
Publisher ID:
PONE-D-20-39982
DOI: 10.1371/journal.pone.0252711
PMC ID: 8224913
PubMed ID: 34166385
SO-VID: b2342927-1d6d-426c-9c6f-a6a7ae33cf70
Copyright © © 2021 Meagher et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 20
December
2020
Date
accepted
: 20
May
2021
Page count
Figures: 9,
Tables: 2,
Pages: 20
Funding
Funded by:
funder-id http://dx.doi.org/10.13039/100004411, Heart and Stroke Foundation of Canada;
Award ID: G-15-0009282
Award Recipient
:
Kim A. Connelly
Funded by:
St. Michael’s Hospital Foundation “SCAR WARS” program
Award Recipient
:
Kim A. Connelly
This study was funded in part by the Heart and Stroke Foundation of Canada in the
form of a grant (G-15-0009282) and by St. Michael’s Hospital Foundation “SCAR WARS”
program in the form of funds, both to KAC. The Department of Medicine, University
of Toronto also provided support in the form of a Merit Award for KAC. The specific
roles of these authors are articulated in the ‘author contributions’ section.
Categories
Subject:
Research Article
Subject:
Medicine and health sciences
Subject:
Pharmaceutics
Subject:
Drug therapy
Subject:
Cardiovascular therapy
Subject:
ACE inhibitor therapy
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Rats
Subject:
Wistar Rats
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Rats
Subject:
Wistar Rats
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Rats
Subject:
Wistar Rats
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Rodents
Subject:
Rats
Subject:
Wistar Rats
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Rodents
Subject:
Rats
Subject:
Wistar Rats
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Kidneys
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Kidneys
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Carbohydrates
Subject:
Monosaccharides
Subject:
Glucose
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Carbohydrates
Subject:
Monosaccharides
Subject:
Glucose
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Fibrosis
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