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      Extrahypothalamic Brain Luteinizing Hormone: Characterization by Radioimmunoassay, Chromatography, Radioligand Assay and Bioassay

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          We have recently reported that luteinizing hormone (LH) is present in the hypothalamus of rats. It has chromatographic and biologic characteristics similar to pituitary LH. In this report we focus on extrahypothalamic LH that is widely distributed in the rodent central nervous system. This material has a chromatographic profile similar to that of pituitary LH. Serial dilution of this material is parallel with dilutions of rat pituitary LH in the immunoassay. Brain extracts are active in the testis LH radioligand receptor assay and in the rat interstitial cell testosterone secretion bioassay. Prior incubation of extract with LH antibody significantly attenuates both of these activities. Thus, extrahypothalamic LH has immunologic, chromatographic, and biologic characteristics similar to hypothalamic and pituitary LH.

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          Author and article information

          S. Karger AG
          26 March 2008
          : 36
          : 4
          : 254-260
          Research and Medical Services, Veterans Administration Hospital, Hines, Ill., and Departments of Medicine and Biochemistry, Loyola University Stritch School of Medicine, Maywood, Ill., USA
          123464 Neuroendocrinology 1983;36:254–260
          © 1983 S. Karger AG, Basel

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          Pages: 7
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