Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol.

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Abstract

Data suggest that estrogen-containing hormone therapy is associated with beneficial effects with regard to cardiovascular disease when the therapy is initiated temporally close to menopause but not when it is initiated later. However, the hypothesis that the cardiovascular effects of postmenopausal hormone therapy vary with the timing of therapy initiation (the hormone-timing hypothesis) has not been tested.

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Journal

Journal ID (iso-abbrev): N. Engl. J. Med.

Title: The New England journal of medicine

ISSN (Electronic): 1533-4406

ISSN (Print): 0028-4793

Publication date (Electronic): Mar 31 2016

Volume: 374

Issue: 13

Affiliations

[1 ] From the Atherosclerosis Research Unit (H.N.H., W.J.M., J.H.-L., Y.L., M.F., L.D., N.K., R.H.S., S.P.A.) and the Departments of Medicine (H.N.H.), Preventive Medicine (H.N.H., W.J.M., L.D., N.K., F.Z.S., S.P.A.), Molecular Pharmacology and Toxicology (H.N.H., J.H.-L.), and Obstetrics and Gynecology (D.S., F.Z.S.), Keck School of Medicine, University of Southern California, Los Angeles, the Departments of Health Research and Policy (Epidemiology) and Neurology and Neurological Sciences, Stanford University, Stanford (V.W.H.),and the Los Angeles Biomedical Research Institute, Harbor-University of California, Los Angeles Medical Center, Torrance (M.J.B.) - all in California.

Article

Mid ID: NIHMS775621

DOI: 10.1056/NEJMoa1505241

PubMed ID: 27028912

SO-VID: b368732d-4e3f-4c4e-b7d2-1c44899fd3da

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