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      Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol.

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          Abstract

          Data suggest that estrogen-containing hormone therapy is associated with beneficial effects with regard to cardiovascular disease when the therapy is initiated temporally close to menopause but not when it is initiated later. However, the hypothesis that the cardiovascular effects of postmenopausal hormone therapy vary with the timing of therapy initiation (the hormone-timing hypothesis) has not been tested.

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          Author and article information

          Journal
          N. Engl. J. Med.
          The New England journal of medicine
          1533-4406
          0028-4793
          Mar 31 2016
          : 374
          : 13
          Affiliations
          [1 ] From the Atherosclerosis Research Unit (H.N.H., W.J.M., J.H.-L., Y.L., M.F., L.D., N.K., R.H.S., S.P.A.) and the Departments of Medicine (H.N.H.), Preventive Medicine (H.N.H., W.J.M., L.D., N.K., F.Z.S., S.P.A.), Molecular Pharmacology and Toxicology (H.N.H., J.H.-L.), and Obstetrics and Gynecology (D.S., F.Z.S.), Keck School of Medicine, University of Southern California, Los Angeles, the Departments of Health Research and Policy (Epidemiology) and Neurology and Neurological Sciences, Stanford University, Stanford (V.W.H.),and the Los Angeles Biomedical Research Institute, Harbor-University of California, Los Angeles Medical Center, Torrance (M.J.B.) - all in California.
          Article
          NIHMS775621
          10.1056/NEJMoa1505241
          27028912

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