Experimental model to study the effect of nicotine in a random skin flap, in the rat

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Abstract

Presentation of an experimental model to study the effect of nicotine in a random skin flap, in the rat. Adult rats of the same lineage are exposed to nicotine for seven days in the preoperative period. After the preoperative period, the animals are anesthetized and a dorsal random pattern skin flap, cranially based is elevated. On the seventh postoperative day, the rats are anesthetized and the percentages of distal necrosis in the flaps are determined. After that, excision of skin fragments for biochemical analysis is possible. Blood samples may be collected by decapitation.

Translated abstract

Apresentação de um modelo experimental para estudar o efeito da nicotina em um retalho cutâneo randômico, no rato. Ratos adultos da mesma linhagem são expostos à nicotina por sete dias no período pré-operatório. Após este período os animais são anestesiados e um retalho cutâneo randômico dorsal, de base cranial é elevado. No sétimo dia de pós-operatório, os ratos são anestesiados e as porcentagens de necrose distal são determinadas. Isto feito, é possível colher fragmentos de pele para análise bioquímica. Amostras de sangue podem ser colhidas por decapitação.

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Most cited references 12

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Skin flap failure: pathophysiology.

C Kerrigan (1983)

An experimental study was undertaken in pigs to clarify the pathophysiologic events occurring in a failing skin flap. It was demonstrated that skin flaps fail because of arterial insufficiency. Arteriovenous shunting is not a major cause of skin flap necrosis.

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Acute effects of cigarette smoking on microcirculation of the thumb.

W Van der Pol, N Rooijen, S Hovius … (1991)

The acute effect of smoking on the microcirculation of the skin of the thumb was investigated in healthy volunteers. Twenty-two were smokers and 10 were non-smokers. The flow was assessed by means of laser Doppler flowmetry. The smokers inhaled 2 cigarettes. During smoking of their first and second cigarette respectively, a mean decrease in laser Doppler flow of 23.8% and 29.0% was seen (p = 0.03; p = 0.01). Ten minutes after smoking this decrease was recovered by half. This experiment confirms that one should prohibit smoking of cigarettes pre- and postoperatively for optimal wound healing conditions.