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      Clinically applicable artificial intelligence system for dental diagnosis with CBCT

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          Abstract

          In this study, a novel AI system based on deep learning methods was evaluated to determine its real-time performance of CBCT imaging diagnosis of anatomical landmarks, pathologies, clinical effectiveness, and safety when used by dentists in a clinical setting. The system consists of 5 modules: ROI-localization-module (segmentation of teeth and jaws), tooth-localization and numeration-module, periodontitis-module, caries-localization-module, and periapical-lesion-localization-module. These modules use CNN based on state-of-the-art architectures. In total, 1346 CBCT scans were used to train the modules. After annotation and model development, the AI system was tested for diagnostic capabilities of the Diagnocat AI system. 24 dentists participated in the clinical evaluation of the system. 30 CBCT scans were examined by two groups of dentists, where one group was aided by Diagnocat and the other was unaided. The results for the overall sensitivity and specificity for aided and unaided groups were calculated as an aggregate of all conditions. The sensitivity values for aided and unaided groups were 0.8537 and 0.7672 while specificity was 0.9672 and 0.9616 respectively. There was a statistically significant difference between the groups (p = 0.032). This study showed that the proposed AI system significantly improved the diagnostic capabilities of dentists.

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          User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability.

          Active contour segmentation and its robust implementation using level set methods are well-established theoretical approaches that have been studied thoroughly in the image analysis literature. Despite the existence of these powerful segmentation methods, the needs of clinical research continue to be fulfilled, to a large extent, using slice-by-slice manual tracing. To bridge the gap between methodological advances and clinical routine, we developed an open source application called ITK-SNAP, which is intended to make level set segmentation easily accessible to a wide range of users, including those with little or no mathematical expertise. This paper describes the methods and software engineering philosophy behind this new tool and provides the results of validation experiments performed in the context of an ongoing child autism neuroimaging study. The validation establishes SNAP intrarater and interrater reliability and overlap error statistics for the caudate nucleus and finds that SNAP is a highly reliable and efficient alternative to manual tracing. Analogous results for lateral ventricle segmentation are provided.
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            Artificial intelligence in radiology

            Artificial intelligence (AI) algorithms, particularly deep learning, have demonstrated remarkable progress in image-recognition tasks. Methods ranging from convolutional neural networks to variational autoencoders have found myriad applications in the medical image analysis field, propelling it forward at a rapid pace. Historically, in radiology practice, trained physicians visually assessed medical images for the detection, characterization and monitoring of diseases. AI methods excel at automatically recognizing complex patterns in imaging data and providing quantitative, rather than qualitative, assessments of radiographic characteristics. In this O pinion article, we establish a general understanding of AI methods, particularly those pertaining to image-based tasks. We explore how these methods could impact multiple facets of radiology, with a general focus on applications in oncology, and demonstrate ways in which these methods are advancing the field. Finally, we discuss the challenges facing clinical implementation and provide our perspective on how the domain could be advanced.
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              Clinically applicable deep learning for diagnosis and referral in retinal disease

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                Author and article information

                Contributors
                call53@yahoo.com
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                22 July 2021
                22 July 2021
                2021
                : 11
                : 15006
                Affiliations
                [1 ]Diagnocat Inc, San Francisco, CA USA
                [2 ]GRID grid.5379.8, ISNI 0000000121662407, Division of Dentistry, School of Medical Sciences, , The University of Manchester, ; Manchester, UK
                [3 ]Private Practice, Orlando, FL USA
                [4 ]GRID grid.412132.7, ISNI 0000 0004 0596 0713, Department of DentoMaxillofacial Radiology, Faculty of Dentistry, , Near East University, ; Nicosia, Cyprus
                [5 ]GRID grid.7256.6, ISNI 0000000109409118, Department of DentoMaxillofacial Radiology, Faculty of Dentistry, , Ankara University, ; 06500 Ankara, Turkey
                [6 ]GRID grid.7256.6, ISNI 0000000109409118, Medical Design Application and Research Center (MEDITAM), , Ankara University, ; Ankara, Turkey
                Article
                94093
                10.1038/s41598-021-94093-9
                8298426
                34294759
                b4357fbe-a8b3-4a41-886d-23f600bc3619
                © The Author(s) 2021

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 6 March 2021
                : 5 July 2021
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                © The Author(s) 2021

                Uncategorized
                medical research,dental diseases
                Uncategorized
                medical research, dental diseases

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