Raloxifene Plus Antipsychotics Versus Placebo Plus Antipsychotics in Severely Ill Decompensated Postmenopausal Women With Schizophrenia or Schizoaffective Disorder: A Randomized Controlled Trial.

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Abstract

Several single-center studies have found raloxifene, an estrogen agonist, to be effective in ameliorating symptoms of schizophrenia in stable patients as augmentation of antipsychotics. This multicenter study assessed whether raloxifene plus antipsychotic treatment, in comparison to placebo plus antipsychotics, improves symptoms or cognition in severely ill decompensated schizophrenia patients.

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Author and article information

Journal

Journal ID (iso-abbrev): J Clin Psychiatry

Title: The Journal of clinical psychiatry

Publisher: Physicians Postgraduate Press, Inc

ISSN (Electronic): 1555-2101

ISSN (Print): 0160-6689

Publication date (Electronic): May 23 2017

Affiliations

[1 ] Department of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel. mweiser@netvision.net.il.

[2 ] Division of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

[3 ] Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.

[4 ] Spitalul Clinic de Psihiatrie Obregia, Bucharest, Romania.

[5 ] Clinica de Psihiatrie, Arad, Romania.

[6 ] Spitalul Clinic Judetean, Sectia Clinica Psihiatrie II, Cluj, Romania.

[7 ] Spitalul Clinic de Urgenta Militar "Dr. Stefan Odobleja," Craiova, Romania.

[8 ] Spitalul Clinic de Psihiatrie "Dr. Gheorghe Preda," Sibiu, Romania.

[9 ] Spitalul Clinic Judetean Mures, Sectia Clinica Psihiatrie I, Târgu Mureș, Romania.

[10 ] St George's, University of London, London, England.

[11 ] Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.

[12 ] Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.

Article

DOI: 10.4088/JCP.15m10498

PubMed ID: 28541645

SO-VID: b44cd6d0-a8ab-4adf-8a43-f6d67b4e4ab4

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