Time Perception and Hemodialysis

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Subtle alterations in neurological function are often difficult to identify and even harder to quantitate. The identification of a neurotoxic state existing before overt behavioral changes occur has eluded quantification. It was hypothesized that a challenging signal-detection procedure would be used to assess neurological function of dialysis patients and other subjects, the degree of uremic toxicity occurring during an interdialytic interval, and the effects of neuroactive drugs. A vigilance task demanding the detection of an irregularly flashing light from a matrix of regularly flashing lights was administered to 3 groups of 15 men: patients undergoing maintenance hemodialysis, patients with chronic illness and no kidney disease, and healthy subjects. The procedure was found to yield a reliable measure; average test-retest correlation was 0.93, which differentiated not only within the hemodialysis cycle (p < 0.001), between groups (p < 0.001), but was also related to the recency of neuroactive drugs ingested (p < 0.01).

Related collections

Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1977

Publication date (Print): 1977

Publication date (Electronic): 28 November 2008

Volume: 19

Issue: 3

Pages: 140-145

Affiliations

Veterans Administration Wadsworth Hospital Center, UCLA Schools of Medicine and Public Health, Los Angeles, Calif, and Frazer Valley College, Vancouver, B. C.

Article

Publisher ID: 180878 Other ID: Nephron 1977;19:140–145

DOI: 10.1159/000180878

PubMed ID: 895964

SO-VID: b4d1b0e0-5170-42ee-ad4a-d5dea4a7b9ba

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 31 July 1976

Date accepted : 30 November 1976

Page count

Pages: 6

Comments

Comment on this article

scite_

Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

Submit here before September 30, 2024