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      Increased MIB-1/Ki-67 Labeling Index as a Predictor of an Aggressive Course in a Case of Prolactinoma

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          Secondary resistance to dopamine agonists is a rare phenomenon in patients with a prolactinoma. We describe a 55-year-old male with a macroprolactinoma initially responding favorably to bromocriptine treatment with normalization of prolactin levels and tumor shrinkage. Two years later, he developed resistance to bromocriptine treatment and subsequently to cabergoline. The aggressive course of the disease necessitated three surgical interventions. Staining of the pituitary tissue revealed a very high MIB/Ki-67 labeling index that increased further in specimens derived from repeated surgery. This case demonstrates that high and increasing levels of the MIB/Ki-67 labeling index may indicate an aggressive course associated with secondary dopamine resistance.

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          Most cited references 7

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          Proliferative Activity and Invasiveness among Pituitary Adenomas and Carcinomas: An Analysis Using the MIB-1 Antibody

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            Pituitary carcinoma

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              Sex-Related Difference in the Growth of Prolactinomas: A Clinical and Proliferation Marker Study

               E Delgrange (1997)

                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                March 2004
                17 March 2004
                : 61
                : 3
                : 111-116
                aDivision of Endocrinology, Kaplan Medical Center, Hebrew University and Hadassah School of Medicine, Jerusalem, and bInstitute of Pathology, cDepartment of Neurosurgery, and dInstitute of Endocrinology, Sheba Medical Center, Tel Hashomer, Israel
                75375 Horm Res 2004;61:111–116
                © 2004 S. Karger AG, Basel

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                Page count
                Figures: 3, References: 27, Pages: 6
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