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Soluble Receptor for Advanced Glycation End-Products Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome.

Author(s): Matthieu Jabaudon, Raiko Blondonnet, Laurence Roszyk, Damien Bouvier, Jules Audard, Gael Clairefond, Mathilde Fournier, Geoffroy Marceau, Pierre Déchelotte, Bruno Pereira, Vincent Sapin, Jean-Michel Constantin

Publication date: 2015-07-15

Journal: American journal of respiratory and critical care medicine

Keywords: pulmonary edema, lung injury resolution, alveolar epithelium, acid aspiration, animal model

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Abstract

Levels of the soluble form of the receptor for advanced glycation end-products (sRAGE) are elevated during acute respiratory distress syndrome (ARDS) and correlate with severity and prognosis. Alveolar fluid clearance (AFC) is necessary for the resolution of lung edema but is impaired in most patients with ARDS. No reliable marker of this process has been investigated to date.

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PubMed ID:: 25932660

DOI:: 10.1164/rccm.201501-0020OC

Keywords: pulmonary edema,lung injury resolution,alveolar epithelium,acid aspiration,animal model

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Keywords: pulmonary edema, lung injury resolution, alveolar epithelium, acid aspiration, animal model

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