Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology.

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Abstract

Atopic dermatitis (AD) is the most common inflammatory disease. Evolving disease models link changes in epidermal growth and differentiation to T(H)2/T(H)22 cytokine activation. However, these models have not been tested by in vivo suppression of T-cell cytokines. Cyclosporine (CsA) is an immunosuppressant that is highly effective for severe disease, but its mechanism in AD skin lesions has not been studied.

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Journal

Journal ID (iso-abbrev): J. Allergy Clin. Immunol.

Title: The Journal of allergy and clinical immunology

ISSN (Electronic): 1097-6825

ISSN (Print): 0091-6749

Publication date (Electronic): Jun 2014

Volume: 133

Issue: 6

Affiliations

[1 ] Laboratory for Investigative Dermatology, Rockefeller University, New York, NY.

[2 ] Department of Dermatology, Tel-Hashomer, Tel Aviv, Israel.

[3 ] Laboratory for Investigative Dermatology, Rockefeller University, New York, NY; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY; Center for Clinical and Translational Science, Rockefeller University, New York, NY.

[4 ] Laboratory for Investigative Dermatology, Rockefeller University, New York, NY; Columbia University College of Physicians and Surgeons, New York, NY.

[5 ] Laboratory for Investigative Dermatology, Rockefeller University, New York, NY; Center for Clinical and Translational Science, Rockefeller University, New York, NY.

[6 ] Laboratory for Investigative Dermatology, Rockefeller University, New York, NY; Department of Dermatology, Jefferson Medical College, Philadelphia, Pa.

[7 ] Division of Dermatology, Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo.

[8 ] Laboratory for Investigative Dermatology, Rockefeller University, New York, NY; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: eguttman@rockefeller.edu.

Article

Publisher Item ID: S0091-6749(14)00357-1 Mid ID: NIHMS577312

DOI: 10.1016/j.jaci.2014.03.003

PubMed ID: 24786238

SO-VID: b6d46ad1-9086-45a4-975a-9843d4636da5

History

Keywords: Atopic dermatitis,S100 proteins,T cell,cyclosporine,epidermal abnormalities,immune

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Keywords: Atopic dermatitis, S100 proteins, T cell, cyclosporine, epidermal abnormalities, immune

Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology.

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Regulatory T cell (Treg) therapy

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