Circulating Opioids and Plasma Renin Activity in Insulin-Dependent Diabetics with Renal Haemodynamic Alterations

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Abstract

Circulating opioids were studied in insulin-dependent diabetics with renal haemodynamic alterations. Higher circulating β-endorphin (β-EP) and lower β-lipotropin (β-LPH) levels were found in patients with glomerular hyperfiltration than in diabetics with normal glomerular filtration rate (GFR) and controls. Moreover, significantly positive correlations between β-EP and GFR, and between β-EP and renal plasma flow were demonstrated in these patients. On the contrary, reduced β-EP levels were observed in diabetics with impaired GFR and overt nephropathy. Plasma renin activity was increased in diabetics with glomerular hyperfiltration and reduced in diabetics with overt nephropathy. Circulating opioids might, therefore, play a role in renal haemodynamic alterations, both in patients with early and advanced glomerular changes.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1987

Publication date (Print): 1987

Publication date (Electronic): 05 December 2008

Volume: 46

Issue: 2

Pages: 194-198

Affiliations

^aDepartment of Internal Medicine, Medical Clinic II, University of Pavia; ^bDepartment of Obstetrics and Gynaecology, University of Modena; ^cFondazione Clinica del Lavoro, Nuclear Medicine Service, University of Pavia, Italy

Article

Publisher ID: 184340 Other ID: Nephron 1987;46:194–198

DOI: 10.1159/000184340

PubMed ID: 2955238

SO-VID: b728cc48-5048-49ec-97f6-86185bf73df2

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 12 September 1986

Page count

Pages: 5

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