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Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.

Author(s): W Powderly, Alastair D Lamb, Rachel Taylor, A J Corran, K Spratt, B Baldwin

Publication date: 1994-09-15

Keywords: Acquired Immunodeficiency Syndrome, microbiology, Amphotericin B, pharmacology, Cryptococcus neoformans, drug effects, enzymology, Drug Resistance, Microbial, genetics, Humans, Microbial Sensitivity Tests, Mutation, Steroid Isomerases

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Abstract

Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol delta 8-->7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.

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PubMed ID:: 7958776

DOI:: 10.1111/j.1574-6968.1994.tb07140.x

ScienceOpen disciplines: Chemistry

Keywords: Acquired Immunodeficiency Syndrome,microbiology,Amphotericin B,pharmacology,Cryptococcus neoformans,drug effects,enzymology,Drug Resistance, Microbial,genetics,Humans,Microbial Sensitivity Tests,Mutation,Steroid Isomerases

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ScienceOpen disciplines: Chemistry

Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.

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