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      Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management.

      CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

      Animals, Canada, epidemiology, Diagnosis, Differential, Humans, Risk Factors, Strongyloides, isolation & purification, Strongyloidiasis, complications, diagnosis, drug therapy, mortality

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          Abstract

          Strongyloidiasis, which is caused by the nematode Strongyloides stercoralis, is a common and persistent infection, particularly in developing countries. In the setting of compromised cellular immunity, it can result in fulminant dissemination with case-fatality rates of over 70%. The majority of new Canadian immigrants come from countries where Strongyloides is highly endemic; therefore, the burden of Strongyloides may be underappreciated in Canada. Because early diagnosis and therapy can have a marked impact on disease outcome, screening for this infection should be considered mandatory for patients who have a history of travel or residence in a disease-endemic area and risk factors for disseminated disease (e.g., corticosteroid use and human T-lymphotropic virus type I infection).

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          Author and article information

          Journal
          10.1503/cmaj.1031698
          514646
          15337730

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