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      Effects of Local Steroid Elution on Chronic Pacing Threshold and Impedance of Endocardial Pacemaker Leads

      ,

      Cardiology

      S. Karger AG

      Pacing threshold, Pacing impedance, Steroid-eluting leads

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          Abstract

          To study the effects of steroid elution on chronic pacing threshold and impedance, a 4-mm<sup>2</sup> surface area lead with steroid (030-368, Telectronics; n = 9) was compared to the same lead without steroid (030-359, Telectronics; n = 9) 3 months after implantation. The pulse duration thresholds of the steroid lead were significantly lower at 0.8, 1.6, 2.5, and 5.0 V. Impedance measured by telemetry at 0.8, 1.6, 2.5, 5.0 and 8.0 V pulse amplitude, and 0.05, 0.25, 0.5 and 1.0 ms pulse duration was imilar for the two leads. Mean impedance was about 650 Ω and did not change from 0.8 to 8.0 V. The local steroid elution reduced the pacing threshold, but had no influence on the impedance. The stable impedance indicates that the impedance of this lead was not modified by pulse-dependent variables and, therefore, can also be correctly determined at pulse amplitudes below 5.0 V.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1993
          1993
          18 November 2008
          : 83
          : 4
          : 240-243
          Affiliations
          Medical Clinic, Department of Cardiology, University Hospital Eppendorf, Hamburg, FRG
          Article
          175976 Cardiology 1993;83:240–243
          10.1159/000175976
          8281540
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Arrhythmias, Electrophysiology and Electrocardiography

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