For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
11
views
10
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      1,014
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Respuesta completa a quimioterapia en 2 pacientes con tumores malignos no seminomatosos de testículo diseminados

      research-article

      Read this article at

      SciELO
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Se reportan los casos de 2 pacientes diagnosticados con tumores malignos no seminomatosos de testículo (coriocarcinoma y carcinoma embrionario) que al momento de su diagnóstico presentaban enfermedad diseminada y que fueron tratados en el Hospital Provincial de Oncología "María Curie" de Camagüey con esquema de poliquimioterapia que incluye cisplatino, bleomicin, vinblastina y adriamicina. En ambos casos se obtuvo una respuesta completa que se mantiene en uno a los 48 meses y en otro a los 45 meses después de finalizado el tratamiento.

          Translated abstract

          The cases of 2 patients who were diagnosed non-seminomatous malignant testicular tumors (choriocarcinoma and embrionary carcinoma) and that on being diagnosed presented disseminated disease and were treated at "Maria Curie" Provincial Oncology Hospital of Camagüey with polychemotherapy scheme including cisplatin, bleomycin, vinblastine and adriamycin, were reported. A complete response was obtained in both cases. It was mantained in one of them at 48 months and in the other at 45 months after concluding the treatment.

          Related collections

          Most cited references10

          • Record: found
          • Abstract: not found
          • Article: not found

          Impact of the Treating Institution on Survival of Patients With "Poor-Prognosis" Metastatic Nonseminoma

          L Collette (1999)
          Article 0 comments Cited 14 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Chemotherapy of disseminated testicular cancer. A random prospective study.

            L H Einhorn, S Williams (1980)
            Seventy-eight patients with disseminated testicular cancer were entered on a random prospective study evaluating three separate remission induction arms. Therapy with cis-diamminedichloroplatinum (20 mg/M2 for five consecutive days every three weeks for 3-4 courses) and bleomycin (30 units intravenous push weekly for 12 consecutive weeks) was constant. Patients were allocated at random to one of the following induction regimens (in combination with platinum plus bleomycin): (1) vinblastine 0.4 mg/kg every three weeks for four courses; (2) vinblastine 0.3 mg/kg every three weeks for four courses; or (3) vinblastine 0.2 mg/kg plus Adriamycin 50 mg/M2 every three weeks for four courses. All patients received maintenance therapy with vinblastine 0.3 mg/kg once a month for 20 months (total therapy two years) unless progressive disease intervened. The incidence of granulocytopenic fever and sepsis was highest with regimen 1, as 9 patients (35%) developed granulocytopenic fever requiring hospitalization and antibiotics; only 4 (15%) patients on regimen 2 developed granulocytopenic fever. No patients on regimen 2 had documented sepsis. Fifty-three patients (68%) achieved complete remission and an additional 11 patients were rendered free of disease with surgical resection of residual localized disease. Fifty-three patients (68%) remain alive and continuously free of disease from 15+ to 39+ months. There was no difference in the complete remission rate or disease-free status with the higher dosage of vinblastine (regimen 1) during remission induction therapy compared to the less toxic lower dosage of vinblastine (regimen 2). This suggests that dosage reduction of vinblastine to 0.3 mg/kg can produce equivalent therapeutic results with diminished toxicity, and we no longer recommend the 0.4 mg/kg vinblastine dosage.
            Article 0 comments Cited 11 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Cancer: Principles and Practice of Oncology

              L Einhorn, JP Richie, W. Shipley … (2001)
              Article 0 comments Cited 2 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Teresa I. Vela Valencia: Role: ND
                Carolina T. Toledo Jiménez: Role: ND
                Yadira Díaz Gestoso: Role: ND
                Orlys Pérez Portuondo: Role: ND
                Journal
                Journal ID (publisher): med
                Title: Revista Cubana de Medicina
                Abbreviated Title: Rev cubana med
                Publisher: ECIMED (Ciudad de la Habana )
                ISSN: 1561-302X
                Publication date (Print): December 2002
                Volume: 41
                Issue: 6
                Page: 0
                Affiliations
                [1 ] Hospital Provincial de Oncología María Curie Cuba
                Article
                Publisher ID: S0034-75232002000600011
                SO-VID: bb934bdd-4c37-44f9-8362-c276d3acf859
                License:

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Cuba

                Self URI (journal page): http://scielo.sld.cu/scielo.php?script=sci_serial&pid=0034-7523&lng=en
                Categories
                Subject: MEDICINE, GENERAL & INTERNAL
                Subject: MEDICINE, LEGAL
                Subject: MEDICINE, RESEARCH & EXPERIMENTAL

                ScienceOpen disciplines: Social law,Medicine,Internal medicine
                Keywords: BLEOMYCIN,BLEOMICINA,DEXORRUBICINA,QUIMIOTERAPIA COMBINADA,METASTASIS DEL NEOPLASMA,TESTICULAR NEOPLASMS,VINBLASTINE,DOXORUBICIN,DRUG THERAPY, COMBINATION,NEOPLASM METASTASIS,NEOPLASMAS TESTICULARES,VINBLASTINA
                Data availability:
                ScienceOpen disciplines: Social law, Medicine, Internal medicine
                Keywords: BLEOMYCIN, BLEOMICINA, DEXORRUBICINA, QUIMIOTERAPIA COMBINADA, METASTASIS DEL NEOPLASMA, TESTICULAR NEOPLASMS, VINBLASTINE, DOXORUBICIN, DRUG THERAPY, COMBINATION, NEOPLASM METASTASIS, NEOPLASMAS TESTICULARES, VINBLASTINA

                Comments

                Comment on this article