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<p class="first" id="d5096470e221">We demonstrate an optimized optical platform for
the three-dimensional (3-D) visualization
of crystalline lens opacities in vivo in the eyes of patients with different types
and grades of cataracts. We developed a prototype long-depth-range swept source optical
coherence tomography (SS-OCT) instrument operating at the speed of 50 kA-scans/second
and at the central wavelength of 1 μm to perform high-resolution imaging of the whole
anterior segment of the eye. Volumetric data sets of cataractous eyes were acquired
and processed to obtain contrast-enhanced high-resolution images of lenticular structures
and opacifications. The results showed lens micro- and macro-scale features related
to possible cataract development such as cortical spokes, water clefts and enhanced
scattering in the lens nucleus. The results demonstrate also the ability of this SS-OCT
imaging to locate and characterize opacities quantitatively. The instrument might
be a useful tool in the high-resolution preoperative evaluation of crystalline lens
opacities in cataract patients.