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      Assisted Reproductive Technology after the Birth of Louise Brown

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          Abstract

          Background

          Public interest in Assisted Reproductive Technology (ART) has remained high since the birth of the world’s first in vitro fertilization baby, Louise Brown, in the United Kingdom. ART allows scientists to manipulate the fertilization process in order to bypass some pathological obstacles such as blocked fallopian tubes and non-functioning ovaries in the females, and blocked vas deferens and low sperm count in the males. The purpose was to provide a historical outline and identify the researches that most contributed to ART.

          Methods

          A review of published experimental and clinical studies of assisted reproduction carried out at the University of Bristol library website (MetaLib ®). A cross-search of seven different medical databases (AMED-Allied and Complementary Medicine Database, BIOSIS Previews on Web of Knowledge, Cochrane Library, Embase, and the Medline on Web of Knowledge, OvidSP and PubMed) was completed by using the key words to explore the major milestones and progress in the development and implementation of ART.

          Results

          A speedy advancement in the development of different assisted reproductive techniques makes infertility problem more treatable than it ever had been.

          Conclusion

          Although no other field in the medicine has integrated new knowledge into the daily practice more quickly than ART yet, there is a need for social research to counterbalance the dominance of biomedical one, in particular the people’s actual experiences and expectations of ART.

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          Most cited references110

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          Livebirth after orthotopic transplantation of cryopreserved ovarian tissue.

          The lifesaving treatment endured by cancer patients leads, in many women, to early menopause and subsequent infertility. In clinical situations for which chemotherapy needs to be started, ovarian tissue cryopreservation looks to be a promising option to restore fertility. In 1997, biopsy samples of ovarian cortex were taken from a woman with stage IV Hodgkin's lymphoma and cryopreserved before chemotherapy was initiated. After her cancer treatment, the patient had premature ovarian failure. In 2003, after freeze-thawing, orthotopic autotransplantation of ovarian cortical tissue was done by laparoscopy. 5 months after reimplantation, basal body temperature, menstrual cycles, vaginal ultrasonography, and hormone concentrations indicated recovery of regular ovulatory cycles. Laparoscopy at 5 months confirmed the ultrasonographic data and showed the presence of a follicle at the site of reimplantation, clearly situated outside the ovaries, both of which appeared atrophic. From 5 to 9 months, the patient had menstrual bleeding and development of a follicle or corpus luteum with every cycle. 11 months after reimplantation, human chorionic gonadotrophin concentrations and vaginal echography confirmed a viable intrauterine pregnancy, which has resulted in a livebirth. We have described a livebirth after orthotopic autotransplantation of cryopreserved ovarian tissue. Our findings suggest that cryopreservation of ovarian tissue should be offered to all young women diagnosed with cancer.
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            Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification.

            Over 200 recessive X chromosome-linked diseases, typically affecting only hemizygous males, have been identified. In many of these, prenatal diagnosis is possible by chorion villus sampling (CVS) or amniocentesis, followed by cytogenetic, biochemical or molecular analysis of the cells recovered from the conceptus. In others, the only alternative is to determine the sex of the fetus. If the fetus is affected by the defect or is male, abortion can be offered. Diagnosis of genetic defects in preimplantation embryos would allow those unaffected to be identified and transferred to the uterus. Here we report the first established pregnancies using this procedure, in two couples known to be at risk of transmitting adrenoleukodystrophy and X-linked mental retardation. Two female embryos were transferred after in vitro fertilization (IVF), biopsy of a single cell at the six- to eight-cell stage, and sexing by DNA amplification of a Y chromosome-specific repeat sequence. Both women are confirmed as carrying normal female twins.
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              Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy.

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                Author and article information

                Journal
                J Reprod Infertil
                J Reprod Infertil
                JRI
                Journal of Reproduction & Infertility
                Avicenna Research Institute
                2228-5482
                2251-676X
                Jul-Sep 2013
                : 14
                : 3
                : 96-109
                Affiliations
                Department of Obstetrics and Gynaecology, Faculty of Medicine, Dammam University, Dammam, Saudi Arabia
                Author notes
                [* ] Corresponding Author: Remah Moustafa Kamel, 4 Tyndall’s Park Road, Clifton, Bristol, BS8 1PG, United Kingdom. E-mail: remahmoustafa@ 123456hotmail.com
                Article
                JRI-14-96
                10.4172/2161-0932.1000156
                3799275
                24163793
                bcda95f1-d036-43f6-b376-c3f3d25be730
                Copyright © 2013 Avicenna Research Institute

                This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

                History
                : 10 April 2013
                : 04 August 2013
                Categories
                Review Article

                assisted reproductive technology,history,infertility management,louise brown,milestones,timelines

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