Neuropeptides terminating in -Arg-Phe-NH(2) (-RFamide) were first discovered in molluscan nervous systems, but were soon recognized to occur widely throughout the invertebrates. Progress in characterizing members of the family in vertebrates has been slower. In mammals, however, it is now clear that there are at least five genes encoding members of the family, and at least five G-protein-coupled receptors at which they act. The tissue distribution of the peptides and their receptors is wide and there are likely to be many different functions. One of the emerging themes from recent research is that these peptides are involved in control of feeding behaviour both in invertebrates and in vertebrates. This would seem to be a remarkable example of conservation of chemical structure and biological function throughout nervous system evolution.