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Anthracycline dose intensification in acute myeloid leukemia.
Hugo F Fernandez
1 ,
Zhuoxin Sun ,
Xiaopan Yao ,
Mark R Litzow ,
Selina M Luger ,
Elisabeth M Paietta ,
Janis Racevskis ,
Gordon W Dewald ,
Rhett P Ketterling ,
John M Bennett ,
Jacob M Rowe ,
Hillard M Lazarus ,
Martin S Tallman
Sep 24 2009
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Abstract
In young adults with acute myeloid leukemia (AML), intensification of the anthracycline dose during induction therapy has improved the rate of complete remission but not of overall survival. We evaluated the use of cytarabine plus either standard-dose or high-dose daunorubicin as induction therapy, followed by intensive consolidation therapy, in inducing complete remission to improve overall survival.