Association of a 4-Locus Gene Model Including IL13, IL4, FCER1B, and ADRB2 With the Asthma Predictive Index and Atopy in Chinese Han Children.

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Abstract

Asthma is a complex and heterogeneous disease. We found gene-gene interactions between IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 in asthmatic Chinese Han children. This 4-locus set constituted an optimal statistical interaction model. We examined associations between the 4-gene model (IL13, IL4, FCER1B, and ADRB2) and the Asthma Predictive Index (API) and atopy in Chinese Han children.

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Journal

Journal ID (iso-abbrev): J Investig Allergol Clin Immunol

Title: Journal of investigational allergology & clinical immunology

Publisher: Esmon Publicidad, SA

ISSN: 1018-9068

ISSN (Print): 1018-9068

Publication date (Electronic): Dec 2018

Volume: 28

Issue: 6

Affiliations

[1 ] Department of Pediatric Pulmonology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

[2 ] Department of Pediatrics, Shanghai EverBetter Pubin Children's Hospital, Shanghai, China.

Article

DOI: 10.18176/jiaci.0272

PubMed ID: 29761786

SO-VID: bed87785-d94c-41de-a8e4-2cad18ff1a82

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Keywords: Asthma Predictive Index,Atopy,Gene model,Single-nucleotide polymorphism

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Keywords: Asthma Predictive Index, Atopy, Gene model, Single-nucleotide polymorphism

Association of a 4-Locus Gene Model Including IL13, IL4, FCER1B, and ADRB2 With the Asthma Predictive Index and Atopy in Chinese Han Children.

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