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Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice
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Abstract
Previous studies have shown that Transforming growth factor-β (TGF-β)/TGFβRII-Smad3
signaling is involved in articular cartilage homeostasis. However, the role of TGF-β/ALK5
signaling in articular cartilage homeostasis has not been fully defined. In this study,
a combination of in vitro and in vivo approaches was used to elucidate the role of
ALK5 signaling in articular cartilage homeostasis and the development of osteoarthritis
(OA).