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Unusual intramolecular N→O acyl group migration occurring during conjugation of (−)-DHMEQ with cysteine
September 2009
September 2009
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Abstract
Previously we found that (-)-DHMEQ, a specific NF-kappaB inhibitor, covalently bound
to a specific cysteine of NF-kappaB component proteins. In the course of formation
of the (-)-DHMEQ and protected cysteine conjugate, we observed an unusual intramolecular
N-->O acyl group migration.