Renal Effects of an Angiotensin II Antagonist in Stroke-Prone Spontaneously Hypertensive Rat

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Abstract

We evaluated the renal effects of the new angiotensin II type 1 (ATI) receptor antagonist, HR 720, in the stroke-prone spontaneously hypertensive rat. Rats were treated with either vehicle, HR 720, MK-954 (a selective ATI receptor antagonist) or enalapril for 6 weeks. Blood pressure was decreased to a similar extent by HR 720, MK-954 and enalapril (203 ± 4, 202 ± 5 and 190 ± 4 vs. 247 ± 4 mm Hg for control). Urinary protein secretion was also decreased (5.2 ± 0.3, 5.3 ± 0.2 and 5.5 ± 0.6 vs. 25.2 ± 4.6 mg/l00g/24h). The glomerular hypertensive change was improved in each drug-treated group (2.0 ± 0.2, 3.3 ± 0.3 and 1.6 ± 0.1 vs. 17.6 ± 1.5%; p < 0.0001). These results show that, in addition to its antihypertensive effect, HR 720 has a beneficial effect on renal function.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1997

Publication date (Print): 1997

Publication date (Electronic): 23 December 2008

Volume: 76

Issue: 4

Pages: 466-471

Affiliations

Department of Geriatric Medicine, Osaka University Medical School, Osaka, Japan

Article

Publisher ID: 190230 Other ID: Nephron 1997;76:466–471

DOI: 10.1159/000190230

PubMed ID: 9274845

SO-VID: c12af705-d484-4761-a580-63e07611bb4d

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 29 October 1996

Page count

Pages: 6

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