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      Renal Effects of an Angiotensin II Antagonist in Stroke-Prone Spontaneously Hypertensive Rat

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          Abstract

          We evaluated the renal effects of the new angiotensin II type 1 (ATI) receptor antagonist, HR 720, in the stroke-prone spontaneously hypertensive rat. Rats were treated with either vehicle, HR 720, MK-954 (a selective ATI receptor antagonist) or enalapril for 6 weeks. Blood pressure was decreased to a similar extent by HR 720, MK-954 and enalapril (203 ± 4, 202 ± 5 and 190 ± 4 vs. 247 ± 4 mm Hg for control). Urinary protein secretion was also decreased (5.2 ± 0.3, 5.3 ± 0.2 and 5.5 ± 0.6 vs. 25.2 ± 4.6 mg/l00g/24h). The glomerular hypertensive change was improved in each drug-treated group (2.0 ± 0.2, 3.3 ± 0.3 and 1.6 ± 0.1 vs. 17.6 ± 1.5%; p < 0.0001). These results show that, in addition to its antihypertensive effect, HR 720 has a beneficial effect on renal function.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1997
          1997
          23 December 2008
          : 76
          : 4
          : 466-471
          Affiliations
          Department of Geriatric Medicine, Osaka University Medical School, Osaka, Japan
          Article
          190230 Nephron 1997;76:466–471
          10.1159/000190230
          9274845
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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