Influence of Extracorporeal Dialysis on Insulin-Induced Human Growth Hormone Secretion in Patients with Acute Renal Failure

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Abstract

The influence of haemodialysis on insulin-induced human growth hormone (HGH) secretion was investigated in 14 patients with acute renal insufficiency. In non-dialysed patients significantly elevated HGH levels were found after insulin stimulation as compared with 16 healthy subjects. The mean insulin-induced HGH values found in non-dialysed patients were 12.4 (0 min), 50.7 (30 min), 51.3 (60 min) and 25.2 ng/ml (120 min) as compared with 3.7, 18.1, 33.5 and 13 ng/ml, respectively, obtained in normal subjects. Abnormal HGH secretion was improved after dialysis despite persistence of a diminished hypoglycaemic effect of insulin.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 28 November 2008

Volume: 12

Issue: 4

Pages: 241-248

Affiliations

2nd Clinic of Internal Medicine, Silesian School of Medicine, Katowice

Article

Publisher ID: 180335 Other ID: Nephron 1974;12:241–248

DOI: 10.1159/000180335

PubMed ID: 4407267

SO-VID: c1c04e1d-1db1-4af1-bdec-8ba66cdd382e

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 07 June 1973

Date accepted : 26 July 1973

Page count

Pages: 8

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