An organocatalytic asymmetric Mannich reaction of allylic ketones with cyclic N-sulfonyl α-iminoester has been developed. By using a saccharide-derived chiral tertiary amino-thiourea catalyst, a range of allylic ketones and N-sulfonyl ketimines reacted smoothly to afford tetrasubstituted α-amino esters in high yields with good to excellent regio-, diastero-, and enantioselectivities.