ScienceOpen:
research and publishing network
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
My ScienceOpen
Sign in
Register
Dashboard
Blog
About
Search
Advanced search
My ScienceOpen
Sign in
Register
Dashboard
Search
Search
Advanced search
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
Blog
About
46
views
0
references
Top references
cited by
17
Cite as...
0 reviews
Review
0
comments
Comment
0
recommends
+1
Recommend
0
collections
Add to
0
shares
Share
Twitter
Sina Weibo
Facebook
Email
3,287
similar
All similar
Record
: found
Abstract
: not found
Article
: not found
Enhanced homing of mesenchymal stem cells to the ischemic myocardium by ultrasound-targeted microbubble destruction
Author(s):
Shigen Zhong
,
Shiyu Shu
,
Zhigang Wang
,
Jie Luo
,
Weiying Zhong
,
Haitao Ran
,
Yuanyi Zheng
,
Yuehui Yin
,
Zhiyu Ling
Publication date
Created:
February 2012
Publication date
(Print):
February 2012
Journal:
Ultrasonics
Publisher:
Elsevier BV
Read this article at
ScienceOpen
Publisher
PubMed
Review
Review article
Invite someone to review
Bookmark
Cite as...
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
In recent years, ultrasound-targeted microbubble destruction (UTMD) has been utilised for the targeted delivery of stem cells. We tested the effects of the myocardial micro-environment changes induced by UTMD on promoting the homing of mesenchymal stem cells (MSCs) to the ischemic myocardium. Dogs were randomly divided into two groups and treated with or without UTMD after the establishment of myocardial infarction models. 4,6-diamino-2-phenyl indole (DAPI) labelled MSCs were transplanted via coronary injections 2 weeks after myocardial infarction in both groups. The results from real-time PCR and western blot analyses indicated that the expression of various cytokines in UTMD-treated dogs was much higher than that observed in non-treated dogs. Histopathological findings demonstrate that ultrasound at a frequency of 1MHz and an intensity of 1.0W/cm(2) provoked inflammatory reactions with mild myocardial damage. Myocardial microenvironment changes caused by UTMD may promote the homing of MSCs to the ischemic myocardium. This non-invasive technique may be a promising method for cardiac cell transplantation therapy. Copyright © 2011 Elsevier B.V. All rights reserved.
Related collections
Stress signalling in stem cells
Author and article information
Journal
Title:
Ultrasonics
Abbreviated Title:
Ultrasonics
Publisher:
Elsevier BV
ISSN (Print):
0041624X
Publication date Created:
February 2012
Publication date (Print):
February 2012
Volume
: 52
Issue
: 2
Pages
: 281-286
Article
DOI:
10.1016/j.ultras.2011.08.013
PubMed ID:
21937069
SO-VID:
c25527d9-0cc5-4c4f-891a-4f48d70c3615
Copyright ©
© 2012
License:
https://www.elsevier.com/tdm/userlicense/1.0/
History
Data availability:
Comments
Comment on this article
Sign in to comment
scite_
Similar content
3,287
Prion protein- and cardiac troponin T-marked interstitial cells from the adult myocardium spontaneously develop into beating cardiomyocytes
Authors:
Mariko Omatsu-Kanbe
,
Yuka Nishino
,
Nozomi Nozuchi
…
The effect of electrical conductivity of myocardium on cardiac pumping efficacy: a computational study
Authors:
Ana Yuniarti
,
Ki Moo Lim
Extracellular Vesicles Promote Arteriogenesis in Chronically Ischemic Myocardium in the Setting of Metabolic Syndrome
Authors:
Laura A Scrimgeour
,
Brittany A. Potz
,
Ahmad Aboul Gheit
…
See all similar
Cited by
16
Materials Chemistry of Nanoultrasonic Biomedicine
Authors:
Hailin Tang
,
Yuanyi Zheng
,
Yu Chen
Potential and problems in ultrasound-responsive drug delivery systems
Authors:
Ying-Zheng Zhao
,
Li-Na Du
,
Cui-Tao Lu
…
The role of ultrasound in enhancing mesenchymal stromal cell‐based therapies
Authors:
Daniel Liu
,
Mujib Ullah
,
Waldo C. Concepcion
…
See all cited by
Version 1
- Current
Version 1