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      An assessment by the Statin Muscle Safety Task Force: 2014 update.

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          Abstract

          The National Lipid Association's Muscle Safety Expert Panel was charged with the duty of examining the definitions for statin-associated muscle adverse events, development of a clinical index to assess myalgia, and the use of diagnostic neuromuscular studies to investigate muscle adverse events. We provide guidance as to when a patient should be considered for referral to neuromuscular specialists and indications for the performance of a skeletal muscle biopsy. Based on this review of evidence, we developed an algorithm for the evaluation and treatment of patients who may be intolerant to statins as the result of adverse muscle events. The panel was composed of clinical cardiologists, clinical lipidologists, an exercise physiologist, and a neuromuscular specialist.

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          Author and article information

          Journal
          J Clin Lipidol
          Journal of clinical lipidology
          1933-2874
          1876-4789
          : 8
          : 3 Suppl
          Affiliations
          [1 ] Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address: robert.rosenson@mssm.edu.
          [2 ] McMaster University, Hamilton, ON, Canada.
          [3 ] Emory University, Atlanta, GA, USA.
          [4 ] Mayo Clinic, Rochester, MN, USA.
          [5 ] Department of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT, USA.
          Article
          S1933-2874(14)00160-3
          10.1016/j.jacl.2014.03.004
          24793443
          c26afd5f-401c-4562-9c93-7715cbb59bfc
          Copyright © 2014 National Lipid Association. Published by Elsevier Inc. All rights reserved.
          History

          Muscle adverse events,Myalgia,Myopathy,Neuromuscular testing,Rhabdomyolysis,Statin intolerance,Statins

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