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Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides

Author(s): Alexander R Rovira , Yitzhak Tor

Publication date Created: July 26 2017

Publication date (Print): July 26 2017

Journal: The Journal of Antibiotics

Publisher: Springer Nature

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Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

Lars Jordheim, David Durantel, Fabien Zoulim … (2013)

Nucleoside analogues have been in clinical use for almost 50 years and have become cornerstones of treatment for patients with cancer or viral infections. The approval of several additional drugs over the past decade demonstrates that this family still possesses strong potential. Here, we review new nucleoside analogues and associated compounds that are currently in preclinical or clinical development for the treatment of cancer and viral infections, and that aim to provide increased response rates and reduced side effects. We also highlight the different approaches used in the development of these drugs and the potential of personalized therapy.

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Fluorescent analogs of biomolecular building blocks: design, properties, and applications.

Renatus W. Sinkeldam, Nicholas J Greco, Yitzhak Tor (2010)

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Inhibitors of ribosome functions.

S Pestka (1970)

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Author and article information

Journal

Title: The Journal of Antibiotics

Abbreviated Title: J Antibiot

Publisher: Springer Nature

ISSN (Print): 0021-8820

ISSN (Electronic): 1881-1469

Publication date Created: July 26 2017

Publication date (Print): July 26 2017

Volume:

Issue:

Article

DOI: 10.1038/ja.2017.87

PMC ID: 5785548

PubMed ID: 28743975

SO-VID: c291d0b3-6503-4d6f-9727-d96f5a74ae0a

Copyright © © 2017

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