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Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury
December 2001
December 2001
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Abstract
Loss of neurons after traumatic brain injury (TBI) might involve dysregulated apoptosis.
Activation of caspase-3 is one hallmark of apoptosis. Therefore, caspase-3 activity
(cleavage of DEVD-afc) was measured in cerebrospinal fluid (CSF) samples (n=113) from
27 patients with TBI at day 1 to 14 after trauma. Caspase-3 activity was detected
in 31 (27.4%) CSF samples with highest values (> 5.5 microM/min) seen at day 2-5 after
trauma. No caspase-3 activity was found in serum from patients or CSF from controls.
The presence of activated caspase-3 in CSF suggests ongoing apoptotic processes during
traumatic brain injury.