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      Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

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          Abstract

          T-705, also known as favipiravir, is a small-molecule inhibitor that is currently in clinical development for the treatment of influenza virus infections. This molecule also inhibits the replication of a broad spectrum of other RNA viruses. The objective of this study was to investigate the antiviral effect of favipiravir on chikungunya virus (CHIKV) replication and to contribute to unravelling the molecular mechanism of action against this virus.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): J. Antimicrob. Chemother.
          Title: The Journal of antimicrobial chemotherapy
          ISSN (Electronic): 1460-2091
          ISSN (Print): 0305-7453
          Publication date (Electronic): Oct 2014
          Volume: 69
          Issue: 10
          Affiliations
          [1 ] Laboratory for Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.
          [2 ] Laboratory for Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium Laboratorio de Entomología Médica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Calle 63D 24-31, Bogotá DC, Colombia.
          [3 ] Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
          [4 ] UMR_D 190 "Emergence des Pathologies Virales" (Aix-Marseille University, IRD French Institute of Research for Development, EHESP French School of Public Health), Marseille, France.
          [5 ] Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.
          [6 ] Laboratorio de Entomología Médica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Calle 63D 24-31, Bogotá DC, Colombia.
          [7 ] Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
          [8 ] Laboratory for Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium johan.neyts@rega.kuleuven.be.
          Article
          Publisher Item ID: dku209
          DOI: 10.1093/jac/dku209
          PubMed ID: 24951535
          SO-VID: c35ecafe-7d5d-429b-9fa0-f4241abc67d6
          Copyright © © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
          History

          Keywords: alphavirus,nsP4,polymerase
          Data availability:
          Keywords: alphavirus, nsP4, polymerase

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