Efficacy and Safety of Ledipasvir/Sofosbuvir With and Without Ribavirin in Patients With Chronic HCV Genotype 1 Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ION Trials.

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Abstract

Interferon-based hepatitis C virus (HCV) therapy is safe and effective among people receiving opioid substitution therapy (OST), but treatment uptake remains low. Our aim was to evaluate the impact of OST and drug use during therapy on completion, adherence, sustained virologic response (SVR12), and safety of ledipasvir/sofosbuvir ± ribavirin.

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Author and article information

Journal

Journal ID (iso-abbrev): Clin. Infect. Dis.

Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1537-6591

ISSN (Print): 1058-4838

Publication date (Electronic): Dec 01 2016

Volume: 63

Issue: 11

Affiliations

[1 ] The Kirby Institute, UNSW Australia, Sydney.

[2 ] Center for HIV and Hepatogastroenterology, Düsseldorf, Germany.

[3 ] Liver Unit, Department of Medicine, St Mary's Hospital, London, United Kingdom.

[4 ] INSERM U954, Universitary Hospital of Nancy, University of Lorraine, Vandoeuvre-les-Nancy, France.

[5 ] Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan, Italy.

[6 ] Division of Infectious Diseases, University of California, San Diego.

[7 ] Gilead Sciences, Foster City, California.

[8 ] Gilead Sciences, Stockley Park, United Kingdom.

Article

Publisher Item ID: ciw580

DOI: 10.1093/cid/ciw580

PubMed ID: 27553375

SO-VID: c3ce0a68-2930-4dc5-8b4c-9531bdcddd99

History

Keywords: DAA,PWID,drug use,hepatitis C virus,opioid substitution therapy

Data availability:

Keywords: DAA, PWID, drug use, hepatitis C virus, opioid substitution therapy

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