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      Analysis of Factors Influencing Depression in Elderly People Living with HIV/AIDS Based on Structural Equation Model: A Cross-Sectional Study in Guangxi, China

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          Abstract

          Purpose

          The purpose of our study is to understand the current status of depression and medical social support in elderly HIV/AIDS, as well as the role of social support on depression, so as to provide a certain reference for reducing the occurrence of depression in the population.

          Methods

          A total of 115 participants with PLWHA (people living with HIV/AIDS) aged 50 years or older were collected in Guilin from December 2021 to July 2022. Depression and medical social support were assessed using the Center for Streaming Depression Scale (CES-D) and the Medical Social Support Scale (MOS-SSS). The structural equation model was used to examine the relationship between medical social support and depression.

          Results

          Sixty-one of 115 participants developed depressive symptoms with a prevalence of 53.0%. The results of univariate analysis showed that ethnicity, health status, mean monthly income, antiviral treatment status, and medical social support influenced PLWHA depression ( P<0.05). Simple linear regression showed that health status (95% CI: −9.901~-2.635), and antiviral treatment status (95% CI: −12.969~-3.394) influent depression ( P<0.05). There were associations between total medical social support, practical support dimension, message and emotional support dimension, social interactive cooperation dimension, emotional support dimension and depression (unadjusted and adjusted for contextual factors) ( P < 0.05). Using multiple linear regression analyses, we found that medical-social support was negatively associated with depression with a standardized effect value of −0.223. PLWHA with higher medical social support had lower prevalence of depression.

          Conclusion

          The results indicate that the prevalence of depression among HIV/AIDS patients in Guilin is high. So the joint efforts of individuals, families, and society are needed to improve the physical and mental health of the PLWHA.

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          Most cited references39

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          The MOS social support survey

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            Meta-analysis of the relationship between HIV infection and risk for depressive disorders.

            Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further examine the relationship between depressive disorders and HIV infection. Meta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (N=2,596) or dysthymic disorder (N=1,822). The frequency of major depressive disorder was nearly two times higher in HIV-positive subjects than in HIV-negative comparison subjects. On the other hand, findings were inconclusive with regard to dysthymic disorder. Rates of depression do not appear to be related to the sexual orientation or disease stage of infected individuals. Although the majority of HIV-positive individuals appear to be psychologically resilient, this meta-analysis provides strong evidence that HIV infection is associated with a greater risk for major depressive disorder. Future research should focus on identifying pathways of risk and resilience for depression within this population.
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              Effect of earlier initiation of antiretroviral treatment and increased treatment coverage on HIV-related mortality in China: a national observational cohort study.

              Overall HIV mortality rates in China have not been reported. In this analysis we assess overall mortality in treatment-eligible adults with HIV and attempt to identify risk factors for HIV-related mortality. We used data from the national HIV epidemiology and treatment databases to identify individuals aged 15 years or older with HIV who were eligible for highly active antiretroviral therapy between 1985 and 2009. Mortality rates were calculated in terms of person-years, with risk factors determined by Cox proportional hazard regression. Treatment coverage was calculated as the proportion of time that patients who were eligible for treatment received treatment, with risk factors for not receiving treatment identified by use of logistic regression. Of 323,252 people reported as having HIV in China by the end of 2009, 145,484 (45%) were identified as treatment-eligible and included in this analysis. Median CD4 count was 201 cells per μL (IQR 71-315) at HIV diagnosis and 194 cells per μL (73-293) when first declared eligible for treatment. Overall mortality decreased from 39·3 per 100 person-years in 2002 to 14·2 per 100 person-years in 2009, with treatment coverage concomitantly increasing from almost zero to 63·4%. By 2009, mortality was higher and treatment coverage lower in injecting drug users (15·9 deaths per 100 person-years; 42·7% coverage) and those infected sexually (17·5 deaths per 100 person-years; 61·7% coverage), compared with those infected through plasma donation or blood transfusion (6·7 deaths per 100 person-years; 80·2% coverage). The two strongest risk factors for HIV-related mortality were not receiving highly active antiretroviral therapy (adjusted hazard ratio 4·35, 95% CI 4·10-4·62) and having a CD4 count of less than 50 cells per μL when first declared eligible for treatment (7·92, 7·33-8.57). An urgent need exists for earlier HIV diagnosis and better access to treatment for injecting drug users and patients infected with HIV sexually, especially before they become severely immunosuppressed. The National Centre for AIDS/STD Control and Prevention of the Chinese Centre for Disease Control and Prevention. Copyright © 2011 Elsevier Ltd. All rights reserved.
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                Author and article information

                Journal
                J Multidiscip Healthc
                J Multidiscip Healthc
                jmdh
                Journal of Multidisciplinary Healthcare
                Dove
                1178-2390
                29 May 2023
                2023
                : 16
                : 1491-1501
                Affiliations
                [1 ]Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University , Guilin, Guangxi, 541199, People’s Republic of China
                [2 ]Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care (Guilin Medical University) , Guilin, Guangxi, 541199, People’s Republic of China
                [3 ]Department of AIDS Control and Prevention, Guilin Center for Disease Control and Prevention , Guilin, Guangxi, 541000, People’s Republic of China
                [4 ]Health Management Unit, Faculty of Humanities and Management, Guilin Medical University , Guilin, Guangxi, 541199, People’s Republic of China
                [5 ]Department of Experimental Teaching Center, School of Public Health, Guilin Medical University , Guilin, Guangxi, 541199, People’s Republic of China
                Author notes
                Correspondence: You Li; Liang Cao, Email liyou121300@163.com; caoliang00552@163.com
                [*]

                These authors contributed equally to this work

                Author information
                http://orcid.org/0000-0002-4728-603X
                Article
                410538
                10.2147/JMDH.S410538
                10238549
                c4b0ca20-f0dc-442a-bb57-62743c7bf262
                © 2023 He et al.

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                : 16 March 2023
                : 22 May 2023
                Page count
                Figures: 3, Tables: 4, References: 41, Pages: 11
                Funding
                Funded by: the Science research and Technology Development project of Guilin city;
                Funded by: the Major Science and Technology Projects in Guangxi;
                This work was funded by the Science research and Technology Development project of Guilin city (20210227-6-1), the Major Science and Technology Projects in Guangxi (GKAA22096026).
                Categories
                Original Research

                Medicine
                older people living with hiv/aids,medical social support,depression,structural equation model,sem

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