+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Comparison of the Relaxing Effect of Dopamine with that of Adenosine, Isoproterenol and Acetylcholine in Isolated Canine Coronary Arteries


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Isolated canine coronary arteries were contracted with prostaglandin F<sub>2</sub>α and the relaxing effects of dopamine, adenosine, isoproterenol and acetylcholine were compared. Relaxation induced by dopamine in phenoxybenzamine-treated arteries was not significantly influenced by propranolol and atropine in concentrations sufficient to shift dose-response curves of isoproterenol and acetylcholine, respectively, to the right. Dose-response curves of isoproterenol were shifted significantly to the left by 2 x 10<sup>–5</sup> M aminophylline. In contrast, the relaxing effect of adenosine was significantly attenuated by aminophylline (5 × 10<sup>–6</sup>–10<sup>–4</sup> M) in a dose-dependent manner. Kinetic analysis showed that aminophylline competitively antagonized the effect of adenosine, and the pA<sub>2</sub> was 5.57. At these concentrations, aminophylline did not alter the relaxing action of dopamine and acetylcholine. It may be concluded that dopamine produces relaxation at a different site and with a different mechanism of action from those of isoproterenol, the effect of the latter being presumably mediated by cellular cyclic AMP, and that dopamine also does not share the site of action with adenosine and acetylcholine. It appears that receptive sites specific for adenosine are present in canine coronary arteries.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 12
          : 5
          : 290-301
          Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto
          158064 Blood Vessels 1975;12:290–301
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 28 February 1975
          : 30 April 1975
          Page count
          Pages: 12

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Dog,Interaction between aminophylline and adenosine,Isoproterenol,Adenosine,Coronary arterial strip,Dopamine


          Comment on this article