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      The Effect of the Hip Flexion Angle in Osteonecrosis of the Femoral Head Based on China‐Japan Friendship Hospital Classification ‐ A Finite Element Study

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          Abstract

          Objective

          The alteration in the mechanical environment of the necrotic area is the primary cause of the collapse observed in osteonecrosis of the femoral head (ONFH). This study aims to evaluate the biomechanical implications of the China‐Japan Friendship Hospital (CJFH) classification system and hip flexion angles on the necrotic area in ONFH using finite element analysis (FEA). The goal is to provide valuable guidance for hip preservation treatments and serve as a reference for clinical diagnosis and therapeutic interventions.

          Methods

          Hip tomography CT scan data from a healthy volunteer was used to create a 3D model of the left hip. The model was preprocessed and imported into Solidworks 2018, based on the CJFH classification. Material parameters and boundary conditions were applied to each fractal model in ANSYS 21.0. Von Mises stresses were calculated, and maximum deformation values were obtained to evaluate the biomechanical effects of the load on the necrotic area and post‐necrotic femur, as well as assess each fractal model's collapse risk.

          Results

          (1) At the same hip flexion angle, maximum deformation followed this order: M Type < C Type < L Type. The L3 type necrotic area experienced the most significant deformation at 0, 60, and 110° angles (1.121, 1.7913, and 1.8239 mm respectively). (2) Under the same CJFH classification, maximum deformation values increased with hip flexion angle (0 < 60 < 110°), suggesting a higher risk of collapse at larger angles. (3) Von Mises stress results showed that the maximum stress was not located in the necrotic area but near the inner and outer edge of the femoral neck, indicating decreased stiffness and strength of the subchondral bone after osteonecrosis.

          Conclusion

          The study found that femoral head collapse risk was higher when the necrotic area was located in the lateral column under the same stress load and flexion angle. Mechanical properties of the necrotic area changed, resulting in decreased bone strength and stiffness. Large‐angle hip flexion is more likely to cause excessive deformation of the necrotic area; thus, ONFH patients should reduce or avoid large‐angle hip flexion during weight‐bearing training in rehabilitation activities.

          Abstract

          Deformation cloud diagram of femur under three hip angles based on CJFH classification.

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          Most cited references39

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          Osteonecrosis of the femoral head: pathophysiology and current concepts of treatment

          Osteonecrosis of the femoral head is a disabling pathology affecting a young population (average age at treatment, 33 to 38 years) and is the most important cause of total hip arthroplasty in this population. It reflects the endpoint of various disease processes that result in a decrease of the femoral head blood flow. The physiopathology reflects an alteration of the vascularization of the fine blood vessels irrigating the anterior and superior part of the femoral head. This zone of necrosis is the source of the loss of joint congruence that leads to premature wear of the hip. Several different types of medication have been developed to reverse the process of ischemia and/or restore the vascularization of the femoral head. There is no consensus yet on a particular treatment. The surgical treatments aim to preserve the joint as far as the diagnosis could be made before the appearance of a zone of necrosis and the loss of joint congruence. They consist of bone marrow decompressions, osteotomies around the hip, vascular or non-vascular grafts. Future therapies include the use of biologically active molecules as well as implants impregnated with biologically active tissue. Cite this article: EFORT Open Rev 2019;4:85-97. DOI: 10.1302/2058-5241.4.180036
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            Osteonecrosis of the Femoral Head

            Osteonecrosis of the femoral head most commonly arises from trauma or corticosteroid and alcohol use but is also associated with blood dyscrasias and metabolic and coagulation disorders. Initial evaluation includes a history and physical examination and plain radiographs. Early-stage osteonecrosis is best evaluated by MRI. The Ficat and Arlet classification system is the most widely used. Nonoperative treatment has been studied using bisphosphonates, anticoagulants, vasodilators, statins, and biophysical modalities. Operative treatment includes core decompression with or without adjuvants, such as autologous bone marrow, whereas total hip arthroplasty is reserved for advanced-stage osteonecrosis in older patients or those who have failed joint-preserving treatment.
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              Osteonecrosis of the femoral head: evaluation and treatment.

              Osteonecrosis of the femoral head may lead to progressive destruction of the hip joint. Although the etiology of osteonecrosis has not been definitely delineated, risk factors include corticosteroid use, alcohol consumption, trauma, and coagulation abnormalities. Size and location of the lesion are prognostic factors for disease progression and are best assessed by MRI. The efficacy of medical management of osteonecrosis with pharmacologic agents and biophysical modalities requires further investigation. Surgical management is based on patient factors and lesion characteristics. Preservation of the femoral head may be attempted in younger patients without head collapse by core decompression with vascularized bone grafts, avascular grafts, bone morphogenetic proteins, stem cells, or combinations of the above or rotational osteotomies. The optimal treatment modality has not been identified. When the femoral head is collapsed, arthroplasty is the preferred option.
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                Author and article information

                Contributors
                sdszylg@163.com
                Journal
                Orthop Surg
                Orthop Surg
                10.1111/(ISSN)1757-7861
                OS
                Orthopaedic Surgery
                John Wiley & Sons Australia, Ltd (Melbourne )
                1757-7853
                1757-7861
                24 August 2023
                October 2023
                : 15
                : 10 ( doiID: 10.1111/os.v15.10 )
                : 2689-2700
                Affiliations
                [ 1 ] The First Clinical Medical School Shandong University of Traditional Chinese Medicine Jinan China
                [ 2 ] Orthopaedic Microsurgery Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan China
                Author notes
                [*] [* ] Address for correspondence Gang Li, Orthopaedic Microsurgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China Tel: 0531‐68617088; Email: sdszylg@ 123456163.com

                Author information
                https://orcid.org/0000-0002-1654-2264
                https://orcid.org/0000-0001-5649-4212
                https://orcid.org/0000-0002-3231-8879
                https://orcid.org/0000-0003-2726-8325
                https://orcid.org/0000-0002-4587-6650
                Article
                OS13865
                10.1111/os.13865
                10549839
                37620939
                c6412034-c8da-4b79-b22c-c25e3f186c98
                © 2023 The Authors. Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 23 July 2023
                : 13 March 2023
                : 25 July 2023
                Page count
                Figures: 8, Tables: 6, Pages: 12, Words: 6991
                Funding
                Funded by: Development Plan of Shandong Traditional Chinese Medicine Science and Technology
                Award ID: 2020Q009
                Funded by: evelopment Plan of Shandong Medical and Health Technology
                Award ID: 2019WS577
                Funded by: National Natural Science Foundation of China , doi 10.13039/501100001809;
                Award ID: 81774333
                Award ID: 82074453
                Award ID: 82205154
                Funded by: nnovation Program of Jinan Clinical Medicine Science and Technology
                Award ID: 202019056
                Categories
                Research Article
                Research Articles
                Custom metadata
                2.0
                October 2023
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.3.4 mode:remove_FC converted:04.10.2023

                biomechanics,china‐japan friendship hospital classification,collapse,finite element analysis,hip flexion angle,osteonecrosis of femoral head

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