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Abstract
We report on the protein-resistant properties of glass substrates coated with novel
copolymers of 2-aminoethyl methacrylate hydrochloride and poly(ethylene glycol) methyl
ether methacrylate (AEM-PEG). In comparison to currently available protein-blocking
polymer systems, such as poly-l-lysine-poly(ethylene glycol), silane-based poly(ethylene
glycol), and poly(ethylene glycol) brushes prepared by surface-initiated polymerization,
the proposed AEM-PEG offers the combined advantages of low cost, simplicity of use,
and applicability in aqueous solutions. We demonstrate the capability of AEM-PEG to
block the surface binding of globular proteins (tubulin), their assemblies (microtubules),
and functional motor proteins (kinesin-1). Moreover, we demonstrate the applicability
of AEM-PEG for surface patterning of proteins in microfluidic devices.