James J. Zhu: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: Writing – original draftRole: Writing
– review & editing
Palaniappan Ramanathan:
ORCID: http://orcid.org/0000-0001-8121-7647
Role: ConceptualizationRole: Data curationRole: Investigation
Elizabeth A. Bishop: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Writing – original
draft
Vivian O’Donnell: Role: ConceptualizationRole: Data curationRole: Investigation
Douglas P. Gladue:
ORCID: http://orcid.org/0000-0002-7894-0233
Role: ConceptualizationRole: Writing – original draftRole: Writing – review & editing
Manuel V. Borca: Role: Funding acquisitionRole: InvestigationRole: ResourcesRole: Writing – review
& editing
Shuhong Zhao: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
14
November
2019
Publication date Collection: 2019
Volume: 14
Issue: 11
Electronic Location Identifier: e0223955
Affiliations
[1
]
USDA-ARS, FADRU, Plum Island Animal Disease Center, Orient, New York, United States
of America
[2
]
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, Tennessee, United
States of America
[3
]
USDA-APHIS, Plum Island Animal Disease Center, Orient, New York, United States of
America
Huazhong Agriculture University, CHINA
Author notes
Competing Interests: The authors have declared that no competing interests exist.
[¤]
Current address: Department of Pathology, University of Texas Medical Branch, Galveston,
Texas, United States of America
Author information
Article
Publisher ID:
PONE-D-19-09661
DOI: 10.1371/journal.pone.0223955
PMC ID: 6855437
PubMed ID: 31725732
SO-VID: c71b92a4-65c6-4637-ab88-efd67ca42ba0
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
The funders had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript. MB received funding from U.S. Department
of Homeland Security under Award Numbers HSHQDC-11-X-00077 and HSHQPM-12-X-00005.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Molecular Development
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Swine
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genetic Interference
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogenesis
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Interferons