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Association between hypercortisolaemia and adipose tissue blood flow in vivo
February 2015
February 2015
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Abstract
An apple-shaped fat distribution is associated with an adverse cardiometabolic phenotype.
Hypercortisolaemia (Cushing's syndrome) is characterised by abdominal fat accumulation
and gluteofemoral fat loss. The mechanisms underpinning this redistribution of fat
mass are unknown. Since adipose tissue blood flow (ATBF) is an important determinant
of lipolytic rate in vivo, we hypothesised that hypercortisolaemia might lead to differential
abdominal and femoral ATBF.