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Activities of flucytosine, fluconazole, amphotericin B, and micafungin in a murine model of disseminated infection by Candida glabrata.

Author(s): Josep Guarro, Marçal Mariné, Carolina Serena, F Pastor, Viviane B. L. Torres

Publication date: 2005-10-31

Journal: Antimicrobial Agents and Chemotherapy

Keywords: Amphotericin B, therapeutic use, Animals, Antifungal Agents, Candida glabrata, drug effects, Candidiasis, drug therapy, mortality, Echinocandins, Fluconazole, Flucytosine, Lipopeptides, Lipoproteins, Male, Mice, Microbial Sensitivity Tests, Peptides, Cyclic

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Abstract

We compared the efficacies of amphotericin B, fluconazole, flucytosine, and micafungin in a systemic murine infection by three isolates of Candida glabrata. Amphotericin B showed the best results, although none of the drugs dramatically reduced mortality or tissue burden in liver or spleen.

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PubMed ID:: 16251323

PMC ID:: 1280170

DOI:: 10.1128/AAC.49.11.4757-4759.2005

ScienceOpen disciplines: Chemistry

Keywords: Amphotericin B,therapeutic use,Animals,Antifungal Agents,Candida glabrata,drug effects,Candidiasis,drug therapy,mortality,Echinocandins,Fluconazole,Flucytosine,Lipopeptides,Lipoproteins,Male,Mice,Microbial Sensitivity Tests,Peptides, Cyclic

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ScienceOpen disciplines: Chemistry

Activities of flucytosine, fluconazole, amphotericin B, and micafungin in a murine model of disseminated infection by Candida glabrata.

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