CLUSTAL X is a new windows interface for the widely-used progressive multiple sequence
alignment program CLUSTAL W. The new system is easy to use, providing an integrated
system for performing multiple sequence and profile alignments and analysing the results.
CLUSTAL X displays the sequence alignment in a window on the screen. A versatile sequence
colouring scheme allows the user to highlight conserved features in the alignment.
Pull-down menus provide all the options required for traditional multiple sequence
and profile alignment. New features include: the ability to cut-and-paste sequences
to change the order of the alignment, selection of a subset of the sequences to be
realigned, and selection of a sub-range of the alignment to be realigned and inserted
back into the original alignment. Alignment quality analysis can be performed and
low-scoring segments or exceptional residues can be highlighted. Quality analysis
and realignment of selected residue ranges provide the user with a powerful tool to
improve and refine difficult alignments and to trap errors in input sequences. CLUSTAL
X has been compiled on SUN Solaris, IRIX5.3 on Silicon Graphics, Digital UNIX on DECstations,
Microsoft Windows (32 bit) for PCs, Linux ELF for x86 PCs, and Macintosh PowerMac.