Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity.

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Abstract

The HLA-DR/DQ region remains the major determinant of susceptibility to type 1 diabetes (T1D) despite the more than 50 risk affecting loci outside human leukocyte antigen (HLA) region that have been identified. We aimed at developing a simple risk estimation based on HLA class II genotyping, which was also tested by analyzing HLA class II effect on the autoantibody seroconversion and further progression to diabetes.

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Journal

Journal ID (iso-abbrev): Pediatr Diabetes

Title: Pediatric diabetes

Publisher: Wiley

ISSN (Electronic): 1399-5448

ISSN (Print): 1399-543X

Publication date (Electronic): July 2016

Volume: 17 Suppl 22

Affiliations

[1 ] Immunogenetics Laboratory, University of Turku, Turku, Finland.

[2 ] Department of Pediatrics, University of Turku, Turku, Finland.

[3 ] Department of Pediatrics, Turku University Hospital, Turku, Finland.

[4 ] Department of Physiology, University of Turku, Turku, Finland.

[5 ] Department of Pediatrics, University of Oulu, PEDEGO Research Unit, MRC Oulu, Oulu, Finland.

[6 ] Department of Pediatrics, Oulu University Hospital, Oulu, Finland.

[7 ] Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

[8 ] Folkhälsan Research Center, Helsinki, Finland.

[9 ] Department of Pediatrics, Tampere University Hospital, Tampere, Finland.

Article

DOI: 10.1111/pedi.12327

PubMed ID: 27411431

SO-VID: ca126baa-6960-4e81-8d8e-5aa2d2b3d1e4

History

Keywords: HLA class II,genetics,islet autoimmunity,type 1 diabetes

Data availability:

Keywords: HLA class II, genetics, islet autoimmunity, type 1 diabetes

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Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity.

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