Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions - atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma.

Related collections

Most cited references 2

Record: found
Abstract: found
Article: not found

Analysis of genomic sequences of 95 papillomavirus types: uniting typing, phylogeny, and taxonomy.

H Delius, Neil A Halpern, David Chan … (1995)

Our aim was to study the phylogenetic relationships of all known papillomaviruses (PVs) and the possibility of establishing a supratype taxonomic classification based on this information. Of the many detectably homologous segments present in PV genomes, a 291-bp segment of the L1 gene is notable because it is flanked by the MY09 and MY11 consensus primers and contains highly conserved amino acid residues which simplify sequence alignment. We determined the MY09-MY11 sequences of human PV type 20 (HPV-20), HPV-21, HPV-22, HPV-23, HPV-24, HPV-36, HPV-37, HPV-38, HPV-48, HPV-50, HPV-60, HPV-70, HPV-72, HPV-73, ovine (sheep) PV, bovine PV type 3 (BPV-3), BPV-5, and BPV-6 and created a database which now encompasses HPV-1 to HPV-70, HPV-72, HPV-73, seven yet untyped HPV genomes, and 15 animal PV types. Three additional animal PVs were analyzed on the basis of other sequence data. We constructed phylogenies based on partial L1 and E6 gene sequences and distinguished five major clades that we call supergroups. One of them unites 54 genital PV types, which can be further divided into eleven groups. The second supergroup has 24 types and unites most PVs that are typically found in epidermodysplasia verruciformis patients but also includes several types typical of other cutaneous lesions, like HPV-4. The third supergroup unites the six known ungulate fibropapillomaviruses, the fourth includes the cutaneous ungulate PVs BPV-3, BPV-4, and BPV-6, and the fifth includes HPV-1, HPV-41, HPV-63, the canine oral PV, and the cottontail rabbit PV. The chaffinch PV and two rodent PVs, Micromys minutus PV and Mastomys natalensis PV, are left ungrouped because of the relative isolation of each of their lineages. Within most supergroups, groups formed on the basis of cladistic principles unite phenotypically similar PV types. We discuss the basis of our classification, the concept of the PV type, speciation, PV-host evolution, and estimates of their rates of evolution.

0 comments Cited 30 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Human papillomavirus type 58 DNA sequence.

S. Iwamoto, T Matsukura, Y Kirii (1991)

The complete nucleotide sequence of human papillomavirus type 58 (HPV 58) DNA cloned from an invasive cervical carcinoma was determined. The HPV 58 genome consists of 7824 nucleotides, containing 37.9% of GC residues, and has a similar genome organization of other HPVs. On the nucleotide sequence level, it conserves the signal sequences for regulation of gene expression as with other genital HPVs and exhibits an extensive homology with HPV 33 (77%). Comparative analysis of amino acid sequences reveals that HPV 58 is closely related with HPVs 16, 31, and 33, and is more distantly related with HPVs 6, 11, 18, and 39. HPVs 58, 16, 31, and 33 can be regarded as a group in HPV.

0 comments Cited 8 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Márcio R Cruz: Role: ND

Daniela M Cerqueira: Role: ND

Waldenor B Cruz: Role: ND

Geni NL Camara: Role: ND

Marcelo M Brígido: Role: ND

Evandro O Silva: Role: ND

Luciano GS Carvalho: Role: ND

Cláudia RF Martins: Role: ND

Journal

Journal ID (publisher): mioc

Title: Memórias do Instituto Oswaldo Cruz

Abbreviated Title: Mem. Inst. Oswaldo Cruz

Publisher: Instituto Oswaldo Cruz, Ministério da Saúde (Rio de Janeiro )

ISSN: 1678-8060

Publication date (Print): May 2004

Volume: 99

Issue: 3

Pages: 281-282

Affiliations

[1 ] Universidade de Brasília Brazil

[2 ] Ministério da Saúde Brazil

[3 ] Hospital Regional da Ceilândia Brasil

[4 ] Hospital de Base do Distrito Federal Brasil

Article

Publisher ID: S0074-02762004000300007

DOI: 10.1590/S0074-02762004000300007

PubMed ID: 15273800

SO-VID: ca9aaeb9-e675-4e0c-a6a4-12053d825112

License:

http://creativecommons.org/licenses/by/4.0/

History

Product

SciELO Brazil

Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0074-0276&lng=en