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      Is Open Access

      Development of a clinical protocol for detection of cervical cancer precursor lesions

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          ABSTRACT

          Objective:

          to develop and validate the content of a clinical protocol aimed at prevention of cervical cancer in primary care.

          Method:

          technological research according to the steps: (1) submission of the project to the research ethics committee; (2) bibliographic survey; (3) elaboration of the clinical protocol; and (4) content validation. In the third step, the information was collected through bibliographic research and gynecology specialists were consulted. For the final step, four judges were selected to evaluate the clinical protocol according to AGREE 2. Domains that reached the minimum level of agreement of 75% in the scores were considered validated.

          Results:

          the scores obtained in each domain of the instrument were as follows: domain 1 (scope and purpose) = 87.5%; domain 2 (stakeholder involvement) = 83.3%; domain 3 (development rigor) = 79.7%; domain 4 (clarity of presentation) = 76.3%; domain 5 (applicability) = 78.1%; and domain 6 (editorial independence) = 85.4.

          Conclusion:

          the clinical protocol proved to be a validated material with scores above the minimum required. The protocol obtained positive recommendations with modifications and went through adjustments in order to make it more effective.

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          Most cited references21

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          AGREE II: advancing guideline development, reporting and evaluation in health care.

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            Guidelines 2.0: systematic development of a comprehensive checklist for a successful guideline enterprise.

            Although several tools to evaluate the credibility of health care guidelines exist, guidance on practical steps for developing guidelines is lacking. We systematically compiled a comprehensive checklist of items linked to relevant resources and tools that guideline developers could consider, without the expectation that every guideline would address each item. We searched data sources, including manuals of international guideline developers, literature on guidelines for guidelines (with a focus on methodology reports from international and national agencies, and professional societies) and recent articles providing systematic guidance. We reviewed these sources in duplicate, extracted items for the checklist using a sensitive approach and developed overarching topics relevant to guidelines. In an iterative process, we reviewed items for duplication and omissions and involved experts in guideline development for revisions and suggestions for items to be added. We developed a checklist with 18 topics and 146 items and a webpage to facilitate its use by guideline developers. The topics and included items cover all stages of the guideline enterprise, from the planning and formulation of guidelines, to their implementation and evaluation. The final checklist includes links to training materials as well as resources with suggested methodology for applying the items. The checklist will serve as a resource for guideline developers. Consideration of items on the checklist will support the development, implementation and evaluation of guidelines. We will use crowdsourcing to revise the checklist and keep it up to date.
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              Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.

              To systematically review evidence on genetic risk factors for carbamazepine (CBZ)-induced hypersensitivity reactions (HSRs) and provide practice recommendations addressing the key questions: (1) Should genetic testing for HLA-B*15:02 and HLA-A*31:01 be performed in patients with an indication for CBZ therapy to reduce the occurrence of CBZ-induced HSRs? (2) Are there subgroups of patients who may benefit more from genetic testing for HLA-B*15:02 or HLA-A*31:01 compared to others? (3) How should patients with an indication for CBZ therapy be managed based on their genetic test results?
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                Author and article information

                Journal
                Rev Lat Am Enfermagem
                Rev Lat Am Enfermagem
                rlae
                Revista Latino-Americana de Enfermagem
                Escola de Enfermagem de Ribeirão Preto / Universidade de São Paulo
                0104-1169
                1518-8345
                17 May 2018
                2018
                : 26
                : e2999
                Affiliations
                [1 ] MSc. in Nursing. Doctor Degree Student. RN, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Deise Maria do Nascimento Sousa- Bolsista CAPES - CNPq 479373/2013-2.
                [2 ] MSc. in Nursing. Doctor Degree Student. RN, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
                [3 ] PhD. in Nursing. Adjunct Professor. RN, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
                [4 ] PhD. Medical Sciences. Professor. Collective Health, Universidade Federal de Ciencias da Saúde de Porto Alegre, Porto Alegre, CE, Brazil.
                [5 ] PhD. in Nursing. Adjunct Professor. RN, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
                Author notes
                Corresponding Author: Mônica Oliveira Batista Oriá Universidade Federal do Ceará. Programa de Pós Graduação em Enfermagem Rua Alexandre Baraúna 1115 Rodolfo Teófilo CEP: 60430-160, Fortaleza, CE, Brasil E-mail: profmonicaoria@ 123456gmail.com
                Article
                00316
                10.1590/1518-8345.2340.2999
                5969826
                29791673
                caab5af8-2a78-455c-b848-c725cc0e1785

                This is an open-access article distributed under the terms of the Creative Commons Attribution License

                History
                : 10 July 2017
                : 12 January 2018
                Page count
                Figures: 9, Tables: 0, Equations: 0, References: 22, Pages: 1
                Categories
                Original Articles

                cervical intraephitelial neoplasia,clinical protocol,validation studies as topic,cervical cancer prevention,women’s health,nursing

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