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      Antithrombotic therapy after bioprosthetic aortic valve implantation: Warfarin versus aspirin, a randomized controlled trial.

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          Abstract

          The optimal medical strategy for prevention of thromboembolic events after surgical bioprosthetic aortic valve replacement (BAVR) is still debated. The objective of this study was to compare warfarin therapy (target INR of 2.0 to 3.0) with aspirin 150mg daily as antithrombotic therapy for the first three months after BAVR with or without concomitant coronary artery bypass grafting (CABG). The aim was to evaluate thromboembolic complications, major bleeding complications and death.

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          Author and article information

          Journal
          Thromb. Res.
          Thrombosis research
          Elsevier BV
          1879-2472
          0049-3848
          Feb 2017
          : 150
          Affiliations
          [1 ] Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Electronic address: sulman_raf@hotmail.com.
          [2 ] Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Electronic address: dastpr@gmail.com.
          [3 ] Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Electronic address: thomas.nikolaj.lilleoer@regionh.dk.
          [4 ] Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Electronic address: christian.moeller.02@regionh.dk.
          [5 ] Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Electronic address: jlund@dadlnet.dk.
          [6 ] Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Electronic address: jens.juel.thiis@regionh.dk.
          [7 ] Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Electronic address: lars.koeber.01@regionh.dk.
          [8 ] Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Electronic address: peter.skov.olsen@regionh.dk.
          Article
          S0049-3848(16)30641-7
          10.1016/j.thromres.2016.11.021
          27914653
          cacd02a4-dee4-46a5-b3a1-c44680cd7380
          History

          Anticoagulation,Aspirin,Bioprosthetic valve,Heart valve prosthesis,Thrombosis

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