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      Recent developments in microfluidic synthesis of artificial cell-like polymersomes and liposomes for functional bioreactors

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      , a)
      Biomicrofluidics
      AIP Publishing LLC

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          Abstract

          Recent advances in droplet microfluidics have led to the fabrication of versatile vesicles with a structure that mimics the cellular membrane. These artificial cell-like vesicles including polymersomes and liposomes effectively enclose an aqueous core with well-defined size and composition from the surrounding environment to implement various biological reactions, serving as a diverse functional reactor. The advantage of realizing various biological phenomena within a compartment separated by a membrane that resembles a natural cell membrane is actively explored in the fields of synthetic biology as well as biomedical applications including drug delivery, biosensors, and bioreactors, to name a few. In this Perspective, we first summarize various methods utilized in producing these polymersomes and liposomes. Moreover, we will highlight some of the recent advances in the design of these artificial cell-like vesicles for functional bioreactors and discuss the current issues and future perspectives.

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          Author and article information

          Contributors
          Journal
          Biomicrofluidics
          Biomicrofluidics
          BIOMGB
          Biomicrofluidics
          AIP Publishing LLC
          1932-1058
          30 March 2021
          March 2021
          30 March 2021
          : 15
          : 2
          : 021301
          Affiliations
          Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH) , 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, South Korea
          Author notes
          [a) ] Author to whom correspondence should be addressed: hyomin@ 123456postech.ac.kr
          Author information
          http://orcid.org/0000-0003-0923-7541
          http://orcid.org/0000-0002-0968-431X
          Article
          PMC8012066 PMC8012066 8012066 5.0048441 BMF21-PS-00054
          10.1063/5.0048441
          8012066
          33833845
          caef0105-6301-492f-a3e8-2a2920929494
          © 2021 Author(s)

          Published under license by AIP Publishing.

          1932-1058/2021/15(2)/021301/13/ $30.00

          History
          : 23 February 2021
          : 18 March 2021
          Page count
          Pages: 13
          Funding
          Funded by: National Research Foundation of Korea https://doi.org/10.13039/501100003725
          Award ID: 2020R1C1C1004642
          Funded by: Korea Health Industry Development Institute https://doi.org/10.13039/501100003710
          Award ID: HP20C0006
          Categories
          Perspectives
          Custom metadata

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