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Abstract
Good Cell and Tissue Culture Practice (GCCP) 2.0 is an updated guidance document from
GCCP 1.0 (published by ECVAM in 2005), which was developed for practical use in the
laboratory to assure the reproducibility of in vitro (cell-based) work. The update
in the guidance was essential as cell models have advanced dramatically to more complex
culture systems and need more comprehensive quality management to ensure reproducibility
and high-quality scientific data. This document describes six main principles to consider
when performing cell culture including characterization and maintenance of essential
characteristics, quality management, documentation and reporting, safety, education
and training, and ethics. The document does not intend to impose detailed procedures
but to describe potential quality issues. It is foreseen that the document will require
further updates as the science and technologies evolve over time.