Resuscitation of the child with multiple injuries is similar to that for adults, except that instrumentation and therapy must be tailored in accordance with variable patient size, emotional maturity, and injury response. Because this response is rapid and often compensatory, there is greater reliance on noninvasive means to diagnose and manage the injured child. Children who suffer multisystem trauma typically present with head injury, followed in decreasing frequency by limb fracture and trauma to the torso. The timing of fracture fixation in a patient with multiple injuries remains controversial. In general, clinical judgment will determine the optimal timing for fracture reduction or operative fracture fixation. Management of an associated vascular injury must take into consideration the mechanism of injury, tissue viability, vessel size, and technical limitations. With appropriate initial resuscitation, careful monitoring, and sound clinical judgement, most injured children can be expected to have a good clinical outcome.