The impact of social capital and mental health on medication adherence among older people living with HIV (PLWH)

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

The number of older people living with HIV (PLWH) is increasing. Although there are many studies affecting medication adherence, research on the impact of social capital and mental health on medication adherence in this particular population is limited.

Method

Data were collected from an ongoing observational prospective cohort study, starting from November 2018, among older PLWH in Sichuan province, China. Five hundred twenty-one participants were interviewed. Social capital consists of the individual and family (IF) scale, and the community and society (CS) scale. The presence of probable depression and probable anxiety were assessed using the CES-D-10 and GAD-7 scales. Adherence was defined as taking ≥80% of prescribed HIV medication in 4 days prior to the interview. Two sets of Firth’ penalized regression analyses were used to estimate the association between social capital, mental health, and medication adherence.

Results

The prevalence of non-adherence was 18.2% (95/521) among older PLWH in this study. After adjusting for significant factors, the CS social capital (OR: 0.92, 95%CI:0.85–0.99, p < 0.05) and probable anxiety (OR:1.73, 95%CI:1.07–2.80, p < 0.05) were associated with non-adherence.

Conclusion

This study highlighted that the effects of social capital and mental health on older PLWH’s adherence, which implied that the need to develop interventions to concern for mental health and enhance CS social capital to help the older PLWH better manage HIV medication adherence.

Related collections

Most cited references 44

Record: found
Abstract: found
Article: not found

HIV infection: epidemiology, pathogenesis, treatment, and prevention.

Gary Maartens, Connie Celum, Sharon R. Lewin (2014)

HIV prevalence is increasing worldwide because people on antiretroviral therapy are living longer, although new infections decreased from 3.3 million in 2002, to 2.3 million in 2012. Global AIDS-related deaths peaked at 2.3 million in 2005, and decreased to 1.6 million by 2012. An estimated 9.7 million people in low-income and middle-income countries had started antiretroviral therapy by 2012. New insights into the mechanisms of latent infection and the importance of reservoirs of infection might eventually lead to a cure. The role of immune activation in the pathogenesis of non-AIDS clinical events (major causes of morbidity and mortality in people on antiretroviral therapy) is receiving increased recognition. Breakthroughs in the prevention of HIV important to public health include male medical circumcision, antiretrovirals to prevent mother-to-child transmission, antiretroviral therapy in people with HIV to prevent transmission, and antiretrovirals for pre-exposure prophylaxis. Research into other prevention interventions, notably vaccines and vaginal microbicides, is in progress. Copyright © 2014 Elsevier Ltd. All rights reserved.

0 comments Cited 274 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

Validating a Shortened Depression Scale (10 Item CES-D) among HIV-Positive People in British Columbia, Canada

Wendy Zhang, Nadia O'Brien, Jamie Forrest … (2012)

Objective To establish the reliability and validity of a shortened (10-item) depression scale used among HIV-positive patients enrolled in the Drug Treatment Program in British Columbia, Canada. Methods The 10-item CES-D (Center for Epidemiologic Studies Depression Scale) was examined among 563 participants who initiated antiretroviral therapy (ART) between August 1, 1996 and June 30, 2002. Internal consistency of the scale was measured by Cronbach’s alpha. Using the original CES-D 20 as primary criteria, comparisons were made using the Kappa statistic. Predictive accuracy of CES-D 10 was assessed by calculating sensitivity, specificity, positive predictive values and negative predictive values. Factor analysis was also performed to determine if the CES-D 10 contained the same factors of positive and negative affect found in the original development of the CES-D. Results The correlation between the original and the shortened scale is very high (Spearman correlation coefficient = 0.97 (P<0.001). Internal consistency reliability coefficients of the CES-D 10 were satisfactory (Cronbach α = 0.88). The CES-D 10 showed comparable accuracy to the original CES-D 20 in classifying participants with depressive symptoms (Kappa = 0.82, P<0.001). Sensitivity of CES-D 10 was 91%; specificity was 92%; and positive predictive value was 92%. Factor analysis demonstrates that CES-D 10 contains the same underlying factors of positive and negative affect found in the original development of the CES-D 20. Conclusion The 10-item CES-D is a comparable tool to measure depressive symptoms among HIV-positive research participants.

0 comments Cited 188 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management.

Heidi Pearson, Carl Frick, David W Pantalone … (2006)

A review of 77 studies employing self-report measures of antiretroviral adherence published 1/1996 through 8/2004 revealed great variety in adherence assessment item content, format, and response options. Recall periods ranged from 2 to 365 days (mode = 7 days). The most common cutoff for optimal adherence was 100% (21/48 studies, or 44%). In 27 of 34 recall periods (79%), self-reported adherence was associated with adherence as assessed with other indirect measures. Data from 57 of 67 recall periods (84%) indicated self-reported adherence was significantly associated with HIV-1 RNA viral load; in 16 of 26 (62%), it was associated with CD4 count. Clearly, the field would benefit from item standardization and a priori definitions and operationalizations of adherence. We conclude that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management.

0 comments Cited 166 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Lei He: 834719676@qq.com

Bin Yu: 891148130@qq.com

Bo Gao:

ORCID: http://orcid.org/0000-0001-5346-7761

gaobo15@126.com

Shujuan Yang: rekiny@126.com

Journal

Journal ID (nlm-ta): BMC Public Health

Journal ID (iso-abbrev): BMC Public Health

Title: BMC Public Health

Publisher: BioMed Central (London )

ISSN (Electronic): 1471-2458

Publication date (Electronic): 11 December 2021

Publication date PMC-release: 11 December 2021

Publication date Collection: 2021

Volume: 21

Electronic Location Identifier: 2252

Affiliations

[1 ]GRID grid.13291.38, ISNI 0000 0001 0807 1581, West China School of Public Health and West China Fourth Hospital, , Sichuan University, ; Chengdu, 610041 Sichuan China

[2 ]GRID grid.419897.a, ISNI 0000 0004 0369 313X, West China Second University Hospital of Sichuan University and Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, ; Chengdu, 610041 Sichuan China

[3 ]Lu County Center for Disease Control and Prevention, Luzhou, 646100 Sichuan China

[4 ]GRID grid.419221.d, ISNI 0000 0004 7648 0872, Sichuan Center for Disease Control and Prevention, ; Chengdu, 610041 Sichuan China

[5 ]Pidu District Center for Disease Control and Prevention, Chengdu, 611730 Sichuan China

Author information

Bo Gao http://orcid.org/0000-0001-5346-7761

Article

Publisher ID: 12251

DOI: 10.1186/s12889-021-12251-0

PMC ID: 8665618

PubMed ID: 34895198

SO-VID: cc37f5d0-ba47-4323-898a-47052f0c38d6

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 28 October 2020

Date accepted : 17 November 2021

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: 71603176

Funded by: Sichuan Science and Technology Program

Award ID: 2019YJ0148

Funded by: Sichuan Provincial Foundation for AIDS Prevention and Control

Award ID: 2018-WJW-02

Funded by: the International Initiative on Spatial Life course Epidemiology

Custom metadata

ScienceOpen disciplines: Public health

Keywords: hiv,social capital,mental health,medication adherence

Data availability:

ScienceOpen disciplines: Public health

Keywords: hiv, social capital, mental health, medication adherence

Comments

Comment on this article

scite_

Cited by 4

See all cited by

Most referenced authors 452

See all reference authors

The impact of social capital and mental health on medication adherence among older people living with HIV (PLWH)

Read this article at

Abstract

Background

Method

Results

Conclusion

Related collections

Hogrefe: SDG 3 Good Health and Well-being

Most cited references 44

HIV infection: epidemiology, pathogenesis, treatment, and prevention.

Validating a Shortened Depression Scale (10 Item CES-D) among HIV-Positive People in British Columbia, Canada

Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management.

Author and article information

Contributors

Journal

Affiliations

Author information

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 161

Cited by 4

Most referenced authors 452