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      Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages

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          Abstract

          We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems.

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          Author and article information

          Journal
          Journal of the American Chemical Society
          J. Am. Chem. Soc.
          American Chemical Society (ACS)
          0002-7863
          1520-5126
          May 26 2017
          June 07 2017
          May 26 2017
          June 07 2017
          : 139
          : 22
          : 7432-7435
          Affiliations
          [1 ]Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang 37673, Republic of Korea
          [2 ]Department of Chemistry, Pohang University of Science and Technology, Pohang 37673, Republic of Korea
          [3 ]Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
          Article
          10.1021/jacs.7b02708
          28538099
          ccb121d4-09b9-4b17-983c-aa2c3112cb1f
          © 2017
          History

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