For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
5
views
71
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      189
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Optical Coherence Tomography Evaluation of Peripapillary and Macular Structure Changes in Pre-perimetric Glaucoma, Early Perimetric Glaucoma, and Ocular Hypertension: A Systematic Review and Meta-Analysis

      systematic-review

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background: This study aimed to assess the differences in the average and sectoral peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell plus inner plexiform layer (mGCIPL), and macular ganglion cell complex (mGCC) thickness using optical coherence tomography (OCT) in patients with pre-perimetric glaucoma (PPG) compared to those with early perimetric glaucoma (EG) and ocular hypertension (OHT).

          Methods: A comprehensive literature search of the PubMed database, the Cochrane Library, and Embase was performed from inception to March 2021. The weighted mean difference (WMD) with the 95% confidence interval (CI) was pooled for continuous outcomes.

          Results: Twenty-three cross-sectional studies comprising 2,574 eyes (1,101 PPG eyes, 1,233 EG eyes, and 240 OHT eyes) were included in the systematic review and meta-analysis. The pooled results demonstrated that the average pRNFL (WMD = 8.22, 95% CI = 6.32–10.12, P < 0.00001), mGCIPL (WMD = 4.83, 95% CI = 3.43–6.23, P < 0.00001), and mGCC (WMD = 7.19, 95% CI = 4.52–9.85, P < 0.00001) were significantly thinner in patients with EG than in those with PPG. The sectoral thickness of pRNFL, mGCIPL, and mGCC were also significantly lower in the EG eyes. In addition, the average pRNFL and mGCC were significantly thinner in the PPG eyes than those in the OHT eyes (pRNFL: WMD = −8.57, 95% CI = −9.88 to −7.27, P < 0.00001; mGCC: WMD = −3.23, 95% CI = −6.03 to −0.44, P = 0.02). Similarly, the sectoral pRNFL and mGCC were also significantly thinner in the PPG eyes than those in the OHT eyes.

          Conclusion: OCT-based measurements of peripapillary and macular structural alterations can be used to distinguish PPG from EG and OHT, which can help understand the pathophysiology of glaucoma at earlier stages. Studies that employ clock hour classification methods and longitudinal studies are needed to verify our findings.

          Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=239798 CRD42021239798

          Related collections

          Most cited references71

          • Record: found
          • Abstract: not found
          • Article: not found

          Measuring inconsistency in meta-analyses.

          Julian P. T. Higgins, Simon Thompson, Jonathan Deeks … (2003)
          Article 0 comments Cited 9658 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Bias in meta-analysis detected by a simple, graphical test

            Jos I. M. Egger, G D Smith, M. Schneider … (1997)
            Article 0 comments Cited 6510 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found
              Is Open Access

              The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.

              Alessandro Liberati, Douglas G. Altman, Jennifer Tetzlaff … (2009)
              Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers, and other users. Since the development of the QUOROM (QUality Of Reporting Of Meta-analysis) Statement--a reporting guideline published in 1999--there have been several conceptual, methodological, and practical advances regarding the conduct and reporting of systematic reviews and meta-analyses. Also, reviews of published systematic reviews have found that key information about these studies is often poorly reported. Realizing these issues, an international group that included experienced authors and methodologists developed PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) as an evolution of the original QUOROM guideline for systematic reviews and meta-analyses of evaluations of health care interventions. The PRISMA Statement consists of a 27-item checklist and a four-phase flow diagram. The checklist includes items deemed essential for transparent reporting of a systematic review. In this Explanation and Elaboration document, we explain the meaning and rationale for each checklist item. For each item, we include an example of good reporting and, where possible, references to relevant empirical studies and methodological literature. The PRISMA Statement, this document, and the associated Web site (http://www.prisma-statement.org/) should be helpful resources to improve reporting of systematic reviews and meta-analyses.
              Article 0 comments Cited 2273 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Journal
                Journal ID (nlm-ta): Front Med (Lausanne)
                Journal ID (iso-abbrev): Front Med (Lausanne)
                Journal ID (publisher-id): Front. Med.
                Title: Frontiers in Medicine
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 2296-858X
                Publication date (Electronic): 01 July 2021
                Publication date Collection: 2021
                Volume: 8
                Electronic Location Identifier: 696004
                Affiliations
                [1] 1Department of Ophthalmology, Second Xiangya Hospital, Central South University , Changsha, China
                [2] 2Hunan Clinical Research Center of Ophthalmic Disease , Changsha, China
                [3] 3Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China
                [4] 4Department of Neurosurgery, Xiangya Hospital, Central South University , Changsha, China
                Author notes

                Edited by: Michele Lanza, University of Campania Luigi Vanvitelli, Italy

                Reviewed by: Je Hyun Seo, Pusan National University, South Korea; Christian Mardin, University of Erlangen Nuremberg, Germany

                *Correspondence: Bing Jiang drjiangb@ 123456csu.edu.cn

                This article was submitted to Ophthalmology, a section of the journal Frontiers in Medicine

                †These authors have contributed equally to this work

                Article
                DOI: 10.3389/fmed.2021.696004
                PMC ID: 8280320
                PubMed ID: 34277670
                SO-VID: ccb5a47c-d7ae-4179-b2ea-59e7376cf22a
                Copyright © Copyright © 2021 Tong, Wang, Zhang, He and Jiang.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 15 April 2021
                Date accepted : 28 May 2021
                Page count
                Figures: 6, Tables: 9, Equations: 1, References: 71, Pages: 18, Words: 9738
                Categories
                Subject: Medicine
                Subject: Systematic Review

                Keywords: pre-perimetric glaucoma,early perimetric glaucoma,ocular hypertension,optical coherence tomography,retinal nerve fiber layer,ganglion cell plus inner plexiform layer,ganglion cell complex
                Data availability:
                Keywords: pre-perimetric glaucoma, early perimetric glaucoma, ocular hypertension, optical coherence tomography, retinal nerve fiber layer, ganglion cell plus inner plexiform layer, ganglion cell complex

                Comments

                Comment on this article